Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery.

Neurochemistry International
Munish KumarSuresh C Tyagi

Abstract

An elevated level of Homocysteine (Hcy) is a risk factor for vascular dementia and stroke. Cysthathionine beta Synthase (CBS) gene is involved in the clearance of Hcy. Homozygous individuals for (CBS-/-) die early, but heterozygous for (CBS-/+) survive with high levels of Hcy. The gamma-Amino Butyric Acid (GABA) presents in the central nervous system (CNS) and functions as an inhibitory neurotransmitter. Hcy competes with GABA at the GABA(A) receptor and affects the CNS function. We hypothesize that Hcy causes a decrease in blood flow to the brain due to increase in vascular resistance (VR) because of arterial remodeling in the carotid artery (CA). Blood pressure and blood flow in CA of wild type (WT), CBS-/+, CBS-/+ GABA(A)-/- double knockout, and GABA(A)-/- were measured. CA was stained with trichrome, and the brain permeability was measured. Matrix Metalloproteinases (MMP-2 and MMP-9), tissue inhibitor of metalloproteinase (TIMP-3, TIMP-4), elastin, and collagen-III expression were measured by real-time polymerase chain reaction (RT-PCR). Results showed an increase in VR in CBS-/+/GABA(A)-/-double knockout>CBS-/+/>GABA(A)-/- compared to WT mice. Increased MMP-2, MMP-9, collagen-III and TIMP-3 mRNA levels were found in GABA(A...Continue Reading

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Citations

Aug 14, 2012·Molecular and Cellular Biochemistry·David LominadzeSuresh C Tyagi
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Natia QipshidzeSuresh C Tyagi
Feb 23, 2011·Vascular Health and Risk Management·Neetu TyagiSuresh C Tyagi
Jan 10, 2012·Hearing Research·Soumi KunduSuresh C Tyagi
Aug 23, 2012·The International Journal of Neuroscience·Alexis LionPhilippe P Perrin
Jan 31, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tiffany L SudduthDonna M Wilcock
Nov 12, 2019·Physiological Genomics·Akash K GeorgeMahavir Singh
Jun 29, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mesia M SteedSuresh C Tyagi
Jan 27, 2018·Indian Journal of Clinical Biochemistry : IJCB·Seema BhargavaSangeeta Choudhury

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