Homocysteine in inflammatory bowel disease: a risk factor for thromboembolic complications?

The American Journal of Gastroenterology
B OldenburgJ C Koningsberger

Abstract

Patients with inflammatory bowel disease (IBD) are at increased risk for thromboembolic events. Hyperhomocysteinemia, which is an established risk factor for arterial as well as venous thrombosis, may be more prevalent in IBD because of vitamin deficiencies. In this retrospective study, we studied the concentrations of total homocysteine (tHcy), cobalamin, folate, and pyridoxine in 231 consecutive patients with IBD, of whom 16 patients had a history of venous thrombosis, and nine a history of arterial thrombosis. Age- and gender-matched healthy volunteers served as controls (n = 102). Homocysteine concentrations in patients were higher (12.3 micromol/L [range 4.6-51.3] vs 11.1 micromol/L [range 3.9-27.6], p = 0.001) and hyperhomocysteinemia tended to be more prevalent in patients than in the controls (11.1% vs 5%, p = 0.07). Folate, cobalamin, creatinine, and pyridoxine concentrations were correlated with tHcy. Folate deficiency was infrequently encountered in IBD patients (4.3%). The tHcy concentration in patients with a history of venous or arterial thrombosis was not higher than in patients without a history of thrombosis (12.7 micromol/L [range 4.6-40.1] and 15.2 micromol/L (range 10.5-26.8) vs 12.3 micromol/L [range 10.5-2...Continue Reading

References

Feb 1, 1986·Mayo Clinic Proceedings·R W TalbotR W Beart
Feb 1, 1973·The British Journal of Surgery·N H Dyer, A M Dawson
Apr 13, 1968·British Medical Journal·A V HoffbrandD L Mollin
Dec 17, 1981·The New England Journal of Medicine·C H HalstedT Tamura
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Apr 1, 1994·Gastroenterology·C E CollinsD S Rampton
Aug 1, 1995·International Journal of Epidemiology·E ArnesenJ E Nordrehaug
Apr 1, 1996·Nature Medicine·K S McCully
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R W EvansL H Kuller
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo

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Citations

Mar 3, 2009·Inflammatory Bowel Diseases·Hideo Yoshida, D Neil Granger
May 9, 2006·Journal of Gastroenterology and Hepatology·Józef DrzewoskiLeszek Czupryniak
Aug 6, 2008·World Journal of Gastroenterology : WJG·Gudrun Scheving ThorsteinssonThomas H Casswall
Feb 21, 2008·World Journal of Gastroenterology : WJG·Hugh James Freeman
May 19, 2010·World Journal of Gastroenterology : WJG·Sabiye AkbulutOzlem Yonem
Sep 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kyle L FlanniganJohn L Wallace
Jun 24, 2005·Inflammatory Bowel Diseases·Satish M Rachapalli
Feb 6, 2007·Inflammatory Bowel Diseases·Markus HaumerGottfried Novacek
May 2, 2013·Therapeutic Advances in Gastroenterology·Clare F DonnellanSimon Lal
Oct 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Emi NakanoHilary J Powers
Oct 14, 2009·Inflammatory Bowel Diseases·A R BarclayR K Russell
Apr 12, 2007·Inflammatory Bowel Diseases·Gerald Weinhouse
May 21, 2005·Inflammatory Bowel Diseases·Anna ZholudevAthos Bousvaros
May 26, 2001·The American Journal of Gastroenterology·I E Koutroubakis
Apr 24, 2001·The American Journal of Gastroenterology·A PapaG Gasbarrini
Jan 27, 2006·World Journal of Gastroenterology : WJG·Silvio DaneseAntonio Gasbarrini
Nov 15, 2006·The American Journal of Gastroenterology·Silvio DaneseMaurizio Vecchi
Sep 28, 2004·The American Journal of Gastroenterology·Rodrigo Quera, Fergus Shanahan
Mar 13, 2009·Diseases of the Colon and Rectum·Francesco Di FabioPhilip H Gordon
Mar 16, 2007·The American Journal of Gastroenterology·Laurent Peyrin-BirouletJean-Louis Guéant
Feb 28, 2002·The American Journal of Gastroenterology·Alfredo PapaAntonio Gasbarrini
Sep 1, 2005·The American Journal of Gastroenterology·Luisa SpinaMaurizio Vecchi
Mar 5, 2005·Digestive Diseases and Sciences·Bas OldenburgGerard P van Berge Henegouwen
May 15, 2003·Current Treatment Options in Gastroenterology·Adrian A. Van Bodegraven, A. Salvador Peña
Jun 7, 2008·Digestive Diseases and Sciences·Edibe KarasuArda Tasatargil
Jun 11, 2005·European Journal of Gastroenterology & Hepatology·Rajaventhan SrirajaskanthanAndrew F Muller
Jun 23, 2009·European Journal of Gastroenterology & Hepatology·Marko BrinarBoris Vucelic
Jun 18, 2010·Cardiovascular Therapeutics·Subrata Chakrabarti, Jane E Freedman
Dec 3, 2010·Journal of Crohn's & Colitis·Giovanni CasellaGabrio Bassotti
Sep 9, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christian S JacksonAlan L Buchman
May 15, 2013·Journal of Gastroenterology and Hepatology·Victoria P TanPeter R Gibson
Oct 8, 2013·Journal of Crohn's & Colitis·Robert V BryantSimon P L Travis
Oct 2, 2019·Annals of the American Thoracic Society·Seema AminChristina Anderlind
Oct 13, 2006·Current Opinion in Gastroenterology·Charles N Bernstein
Dec 1, 2007·Journal of Crohn's & Colitis·Dietlind Schleiermacher, Jörg C Hoffmann
Apr 2, 2011·Journal of Crohn's & Colitis·Lamia KallelAzza Filali
Dec 23, 2003·The American Journal of Gastroenterology·Craig A SolemWilliam J Sandborn
Sep 9, 2005·World Journal of Gastroenterology : WJG·Hasan UmitAli-Riza Soylu

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