Homocysteine in ocular diseases

Clinica Chimica Acta; International Journal of Clinical Chemistry
Thekkuttuparambil Ananthanarayanan Ajith, Ranimenon

Abstract

Homocysteine (Hcy) is a derived sulfur-containing and non-proteinogenic amino acid. The metabolism of Hcy occurs either through the remethylation to methionine or transsulfuration to cysteine. Studies have identified hyperhomocysteinemia (HHcy) as one of the possible risk factors for a multitude of diseases including vascular, neurodegenerative and ocular diseases. Association of HHcy with eye diseases such as retinopathy, pseudoexfoliative glaucoma maculopathy, cataract, optic atrophy and retinal vessel atherosclerosis is established. The molecular mechanism underlying these ocular diseases has been reported as impaired vascular endothelial function, apoptosis of retinal ganglion cells, extracellular matrix alterations, decreased lysyl oxidase activity and oxidative stress. The formed homocysteine-thiolactone in HHcy has stronger cytotoxicity and pro-inflammatory properties which can induce lens opacification and optic nerve damage. The metabolism of Hcy requires enzymes with vitamins such as folic acid, vitamins B12 and B6. Despite the mixed conclusion of various studies regarding the level of these vitamins in elder people, studies recommended the treatment with folate and B12 to reduce Hcy levels in subjects with or without...Continue Reading

References

Dec 1, 1990·Trends in Pharmacological Sciences·M CuenodP Streit
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Jun 1, 1993·Free Radical Biology & Medicine·A J Olszewski, K S McCully
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A LiptonJ S Stamler
Nov 26, 1998·The British Journal of Ophthalmology·D C Broadway, S M Drance
Aug 7, 1999·Lancet·G J Hankey, J W Eikelboom
Feb 3, 2000·The British Journal of Ophthalmology·M CahillI Graham
Feb 15, 2001·Current Opinion in Neurology·G J Hankey, J W Eikelboom
Dec 6, 2001·Annals of Clinical Biochemistry·R Clarke, D Stansbie
Jul 3, 2002·The Journal of Biological Chemistry·Hieronim Jakubowski
Jul 27, 2002·European Journal of Clinical Nutrition·R K Chandra
Dec 18, 2002·Journal of Neural Transmission·S BleichJ Kornhuber
Feb 11, 2003·Journal of Cellular Biochemistry·Herbert M Kagan, Wande Li
Feb 20, 2003·Trends in Neurosciences·Mark P Mattson, Thomas B Shea
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·Patricia A FischerLucas D Masnatta
Dec 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Hieronim Jakubowski
Dec 9, 2003·Amino Acids·A F PernaN G De Santo
Jan 1, 2004·American Journal of Ophthalmology·Ruth Axer-SiegelBen-Ami Sela
Jan 8, 2004·Clinical Chemistry·Rima ObeidWolfgang Herrmann
Feb 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bakri O SaeedJolanta U Weaver
Mar 5, 2004·Cellular and Molecular Life Sciences : CMLS·H Jakubowski
Mar 12, 2004·American Journal of Ophthalmology·Gloria WangRobert N Weinreb
Feb 5, 2005·Analytical Biochemistry·Grazyna Chwatko, Hieronim Jakubowski
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Clinton B WrightCharles DeCarli
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Hieronim Jakubowski
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Olaf StangerWolfgang Herrmann
Dec 14, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Erh-Jung HuangShin-Da Lee
Jan 3, 2006·American Journal of Ophthalmology·Johanna M SeddonRoy C Milton
Aug 26, 2006·Journal of Neural Transmission·J B RoedlA G M Jünemann
Feb 8, 2007·Amino Acids·J Perła-KajánH Jakubowski
Sep 28, 2007·Diabetes Care·Laima BrazionisKerin O'Dea
Sep 28, 2007·Investigative Ophthalmology & Visual Science·Ying DunSylvia B Smith
Dec 1, 2007·Clinical Interventions in Aging·Jennie L Wells, Andrea C Dumbrell
Apr 26, 2008·Ophthalmic Research·J B RoedlA G M Jünemann
Jun 21, 2008·The Journal of Physiology·Timothy S Kern, Alistair J Barber
Jun 21, 2008·Investigative Ophthalmology & Visual Science·Karunakaran CoralSubramanian Krishnakumar

❮ Previous
Next ❯

Citations

Oct 13, 2017·Journal of Neurochemistry·Andrea N Beltrán GonzálezDaniel J Calvo
Nov 15, 2018·Physiological Reviews·Hieronim Jakubowski
Aug 5, 2017·Chinese Medical Journal·Wen-Ming Wang, Hong-Zhong Jin
Mar 2, 2018·International Ophthalmology·Duygu Gulmez SevimAyse Ozturk Oner
Mar 7, 2020·Biomolecules·Nehal M ElsherbinyAmany Tawfik
Jan 10, 2020·International Ophthalmology·Fotios S FousekisDimitrios K Christodoulou
Sep 1, 2020·Current Eye Research·Marycruz Flores-FloresMarcos Nahmad
Aug 6, 2020·Biomolecules·Amany TawfikMohamed Al-Shabrawey
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Chengshou ZhangYibo Yu
Mar 20, 2020·MMW Fortschritte der Medizin·Meinrad LindschingerWillibald Wonisch
Jan 24, 2019·Journal of Clinical Medicine·Amany TawfikMohamed Al-Shabrawey
Jun 5, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zhongjing LinYisheng Zhong
Nov 8, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Amany TawfikMohamed Al-Shabrawey
Jul 3, 2021·International Journal of Molecular Sciences·Amany TawfikPragya Rajpurohit
Aug 10, 2021·American Journal of Ophthalmology Case Reports·Michael J AmmarCarl D Regillo
Aug 29, 2021·Pharmaceuticals·Anna Matysik-WoźniakRobert Rejdak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
T Laskowska-Klita
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
G AlemánN Torres
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Antonio SiniscalchiGiovambattista De Sarro
© 2021 Meta ULC. All rights reserved