Homocysteine in vascular Behcet disease: a meta-analysis

Arteriosclerosis, Thrombosis, and Vascular Biology
Micaela La ReginaFrancesco Dentali

Abstract

Behçet disease (BD) is a vasculitis of unknown etiology, characterized by oral or genital aphtosis and uveitis. Homocysteine (hcy) is an independent risk factor for venous and arterial thrombosis. The association between hyperhomocysteinemia and thrombosis has been investigated in some studies in BD patients. However, information on this association is based only on the results of small studies with conflicting results. To overcome such limitations, we performed a metaanalysis comparing the plasma levels of hcy in BD patients with and without history of thrombosis. We searched for all published studies using the Medline and Embase databases. Two reviewers performed study selection independently. Studies were included if hcy was measured in adult BD patients with and without thrombosis. Two reviewers independently extracted data on study and population characteristics. The mean value of hcy in BD patients and the presence of hyperhomocysteinemia in patients with and without thrombosis were collected. Association between thrombosis and hyperhomocysteinemia, and the mean difference of hcy levels in BD patients with and without thrombosis were calculated. Sixteen studies, for a total of 979 patients, were included. Hyperhomocystein...Continue Reading

References

Aug 1, 1987·American Journal of Epidemiology·M Maclure, W C Willett
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 21, 1996·The New England Journal of Medicine·M den HeijerF R Rosendaal
Apr 1, 1996·The Journal of Nutrition·P C HarpelW Borth
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
Oct 21, 1999·The New England Journal of Medicine·T SakaneG Inaba
Sep 6, 2000·Journal of Internal Medicine·A AltinbaşS V Dündar
Jun 27, 2001·Rheumatology·K AksuE Doğanavşargil
Apr 18, 2002·Thrombosis Research·Sedat KirazMeral Calgüneri
Jul 18, 2002·Rheumatology International·Ali KoşarYaşar Karaaslan
Aug 8, 2002·Thrombosis Research·Yun Jong LeeYeong Wook Song
Aug 16, 2003·Advances in Experimental Medicine and Biology·H HoumanM Miled
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 25, 2003·Rheumatology International·Abdullah CanatarogluFikri Baslamisli
Oct 31, 2003·Rheumatology International·Aşkin AteşMurat Duman
Apr 2, 2004·Rheumatology International·Zeki YesilovaIsmail H Kocar
Aug 4, 2004·British Journal of Haematology·Silvia NavarroFrancisco España
Oct 14, 2004·Annals of the Rheumatic Diseases·M LeibaM Ehrenfeld
Nov 24, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Thomas McGinnUNKNOWN Evidence-Based Medicine Teaching Tips Working Group
Mar 2, 2005·Rheumatology International·Meral KayikçioğluEker Doganavsargil
Mar 16, 2005·Journal of Vascular Surgery·Francesco SofiDomenico Prisco
Mar 15, 2006·The New England Journal of Medicine·Kaare Harald BønaaUNKNOWN NORVIT Trial Investigators
Mar 14, 2007·Archives of Internal Medicine·Irene D BezemerFrits R Rosendaal

❮ Previous
Next ❯

Citations

Aug 25, 2011·Genetic Testing and Molecular Biomarkers·Efrat DaganRuth Gershoni-Baruch
Aug 13, 2013·Case Reports in Rheumatology·Nurşen DüzgünAşkın Ateş
Mar 25, 2014·Ocular Immunology and Inflammation·Ebru EsenNihal Demircan
Dec 29, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M Cem ArHasan Yazici
Apr 18, 2015·Thrombosis Journal·Giacomo EmmiDomenico Prisco
Mar 25, 2014·Clinical Rheumatology·Antonio VitaleLuca Cantarini
Nov 2, 2013·Expert Review of Cardiovascular Therapy·Elena SilvestriDomenico Prisco
May 7, 2016·Current Opinion in Cardiology·Sevket BaltaAtila Iyisoy
Jan 17, 2014·International Journal of Rheumatic Diseases·Soraya ShadmanfarFereydoun Davatchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.