Homocysteine is a potent modulator of plasma membrane electron transport systems.

Journal of Bioenergetics and Biomembranes
Javier Rodríguez-AlonsoMiguel Angel Medina

Abstract

The deregulation of homocysteine metabolism leads to hyperhomocysteinemia, a condition described as an independent cardiovascular disease risk factor. Ubiquitous plasma membrane redox systems can play a dual pro-oxidant and anti-oxidant role in defense. In this study, we test the hypothesis that homocysteine, as a redox active compound, could modulate the endothelial plasma membrane redox system. We show that homocysteine behaves as a very potent stimulator of this activity. Furthermore, we show that this inducing effect is also produced on tumor cells and that it can be observed at both the activity and protein levels. On the other hand, homocysteine treatment decreases the activity of the specific ectocellular tumor NADH oxidase. Taken together, these results underscore a potential antitumoral action of homocysteine.

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Citations

Oct 31, 2008·Cellular and Molecular Neurobiology·Olivera StanojlovićDragan Djuric
Sep 4, 2010·Antioxidants & Redox Signaling·Domenico Del PrincipeMaria Valeria Catani
Feb 25, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Leonor Côrte-RealFernanda Marques
May 21, 2016·Redox Report : Communications in Free Radical Research·Elena Díaz-SantiagoMiguel Ángel Medina

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