Homocysteine levels, haemostatic risk factors and patency rates after endovascular treatment of the above-knee femoro-popliteal artery

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
E LaxdalS Aune

Abstract

To investigate the relationship between plasma homocysteine and other haemostatic variables and restenoses or reocclusions after endovascular treatment of symptomatic atherosclerosis of the above-knee femoro-popliteal artery. Prospective observational study. University hospital. The study included 103 patients (116 limbs), treated with subintimal angioplasty in 58 cases (50%) and with intraluminal PTA in 58 (50%): 39 (34%) patients were treated for critical limb ischaemia. Blood samples for analyses of fasting plasma values of homocysteine, fibrinogen, D-dimer, activated protein C resistance were drawn upon admission. Median follow-up for all procedures was 11 months (range 0-42 months). Outcome events (arterial patency) were defined as > or =50% restenosis or reocclusion in the treated arterial segment. Patency rates were estimated with the product limit method and Kaplan-Meier curves. Variables found to be related significantly to patency were included in multivariate analysis performed with the Cox proportional hazard model. The 1-year cumulative primary patency rate for all procedures was 48%. One-year limb salvage rate in cases of critical ischaemia was 74%. Multivariate analysis demonstrated significant independent associ...Continue Reading

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Citations

Jan 19, 2008·BMC Cardiovascular Disorders·Renata HillenbrandJulian Zimmermann
Apr 22, 2008·Journal of Medical Case Reports·Theodossios P PerdikidesDimitrios K Filippou
Mar 29, 2013·Annals of Vascular Surgery·Louai RazzoukAnvar Babaev
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Jul 3, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J BownA J Sutton
Dec 6, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E LaxdalS Aune
Feb 1, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Knut Kröger
Jul 1, 2009·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Nicolas W Shammas
Jun 14, 2016·Journal of Comparative Effectiveness Research·Thomas G Poder, Jean-François Fisette
Jan 8, 2011·Journal of Vascular Surgery·Merel HuismanJoost A van Herwaarden
Mar 29, 2008·Vascular Medicine·Christopher D OwensMichael S Conte

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