Homocysteine levels in patients classified according to Lesch's typology

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
S BleichW Sperling

Abstract

It has been suggested that elevated total plasma homocysteine levels might be useful to predict alcohol withdrawal seizures. The typology by Lesch distinguishes between four subtypes of which type 1 suffers from marked withdrawal symptoms, including alcohol withdrawal seizures. This study was undertaken to investigate total plasma homocysteine levels in actively drinking patients with alcoholism who were classified according to Lesch's typology. We determined total plasma homocysteine levels in 144 non-abstinent chronic alcoholics (115 men, 29 women; aged 22-67 years). Patients were classified in Lesch's typology (LT) and were divided into two groups: LT 1 (n = 27) and LT 2-4 (n = 117). Within the groups, patients with or without a history of alcohol withdrawal seizures were differentiated. All patients with a history of alcohol withdrawal seizures had significantly elevated plasma homocysteine concentrations at admission when compared with those without seizures (Mann-Whitney U, P < 0.001). Furthermore, patients classified as LT 1 who suffered from an alcohol withdrawal seizure (n = 12) had significantly higher plasma homocysteine levels (Z = -2.31, P = 0.02) when compared to the corresponding types 2-4 (n = 24). Using a logis...Continue Reading

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Citations

Feb 3, 2009·Neuropsychology Review·Lorenzo LeggioRobert M Swift
Oct 4, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Samuel Pombo, Otto Michael Lesch
Apr 22, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Wolfgang SperlingUdo Reulbach
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Oct 19, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Thomas HillemacherStefan Bleich
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