Homocysteine lowering with folic acid and B vitamins in vascular disease

The New England Journal of Medicine
Eva LonnHeart Outcomes Prevention Evaluation (HOPE) 2 Investigators

Abstract

In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease. We randomly assigned 5522 patients 55 years of age or older who had vascular disease or diabetes to daily treatment either with the combination of 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12 or with placebo for an average of five years. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, and stroke. Mean plasma homocysteine levels decreased by 2.4 micromol per liter (0.3 mg per liter) in the active-treatment group and increased by 0.8 micromol per liter (0.1 mg per liter) in the placebo group. Primary outcome events occurred in 519 patients (18.8 percent) assigned to active therapy and 547 (19.8 percent) assigned to placebo (relative risk, 0.95; 95 percent confidence interval, 0.84 to 1.07; P=0.41). As compared with placebo, active treatment did not significantly decrease the risk of death from cardiovascular causes (relative risk, 0.96; 95 percent confidence inter...Continue Reading

References

Sep 12, 1974·The New England Journal of Medicine·L A HarkerR Ross
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
Sep 4, 1999·Annals of Internal Medicine·J W EikelboomS Yusuf
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
Oct 22, 2002·JAMA : the Journal of the American Medical Association·Mariska KlerkUNKNOWN MTHFR Studies Collaboration Group
Nov 26, 2002·BMJ : British Medical Journal·David S WaldJoan K Morris
Jun 25, 2003·Journal of the American College of Cardiology·Anho LiemDirk J van Veldhuisen
Oct 8, 2005·The American Journal of Clinical Nutrition·UNKNOWN Homocysteine Lowering Trialists' Collaboration
Jan 31, 2006·American Heart Journal·UNKNOWN B-Vitamin Treatment Trialists' Collaboration
Mar 15, 2006·The New England Journal of Medicine·Kaare Harald BønaaUNKNOWN NORVIT Trial Investigators

❮ Previous
Next ❯

Citations

Nov 6, 2008·JAMA : the Journal of the American Medical Association·Shumin M ZhangJoann E Manson
Nov 3, 2012·JAMA : the Journal of the American Medical Association·Howard D SessoJ Michael Gaziano
Nov 22, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M G H van OijenF W A Verheugt
Apr 30, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dan FengJing Ma
Apr 12, 2012·Cellular and Molecular Life Sciences : CMLS·Scott GleimJohn Hwa
Sep 12, 2007·Der Nervenarzt·R WeberM Grond
Jun 7, 2013·Diabetologia·Zubin PunthakeeHertzel C Gerstein
Nov 1, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S Sacco, A Carolei
Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Franca MoschianoGennaro Bussone
Jun 2, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giuseppe SalemiI Lupo
Jul 1, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Carlijn R HooijmansAmanda J Kiliaan
Nov 12, 2010·Journal of Inherited Metabolic Disease·Robert ClarkeSarah Lewington
Jul 20, 2006·Breast Cancer Research and Treatment·Yu-Ching ChouChien-An Sun
Jul 7, 2012·Cancer Causes & Control : CCC·Joanne KotsopoulosSteven A Narod
Jun 10, 2010·Journal of Thrombosis and Thrombolysis·A W M JanssenM C H Janssen
Nov 11, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jiangtao YanDaowen Wang
Feb 5, 2008·Current Atherosclerosis Reports·Jacqueline Suk Danik, Paul M Ridker
Nov 16, 2007·Current Atherosclerosis Reports·Bradley A Maron, Joseph Loscalzo
Apr 2, 2008·Current Atherosclerosis Reports·Caroline Moats, Eric B Rimm
Oct 22, 2008·Current Atherosclerosis Reports·Venket Rao, Amir Al-Weshahy
Mar 5, 2011·Current Atherosclerosis Reports·Dan FarbsteinAndrew P Levy
Aug 2, 2006·Current Diabetes Reports·Michaela Diamant, Maarten E Tushuizen
Jun 16, 2010·Current Hypertension Reports·Koon K Teo, Yan Liang
Jan 16, 2007·Current Neurology and Neuroscience Reports·J David Spence
Oct 22, 2010·Current Neurology and Neuroscience Reports·Harold P Adams
Mar 8, 2008·Current Treatment Options in Cardiovascular Medicine·Mark Y Chan, Richard C Becker
Jun 2, 2009·Cardiovascular Toxicology·Jacob JosephJoseph Loscalzo
Nov 1, 2011·Cell Biochemistry and Biophysics·Jessica A SipkensHans W M Niessen
Jun 6, 2009·Genes & Nutrition·John C Mathers
Jun 17, 2008·Journal des maladies vasculaires·C Le HelloJ Constans
Aug 21, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Z RafeqJ Joseph
Nov 18, 2006·Lancet Neurology·Hans-Christoph Diener
Oct 3, 2006·Public Health Nutrition·Mark Lawrence
Apr 14, 2011·The British Journal of Nutrition·Valentina LottoSimonetta Friso

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