Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate

American Journal of Epidemiology
P VerhoefW C Willett

Abstract

Elevated plasma homocyst(e)ine levels are an independent risk factor for vascular disease. In a case-control study, the authors studied the associations of fasting plasma homocyst(e)ine and vitamins, which are important cofactors in homocysteine metabolism, with the risk of myocardial infarction. The cases were 130 Boston area patients hospitalized with a first myocardial infarction and 118 population controls, less than 76 years of age, enrolled in 1982 and 1983. Dietary intakes of vitamins B6, B12, and folate were estimated from a food frequency questionnaire. After adjusting for sex and age, the authors found that the geometric mean plasma homocyst(e)ine level was 11% higher in cases compared with controls (p = 0.006). There was no clear excess of cases with extremely elevated levels. The age- and sex-adjusted odds ratio for each 3-mumol/liter (approximately 1 standard deviation) increase in plasma homocyst(e)ine was 1.35 (95% confidence interval 1.05-1.75; p trend = 0/007). After further control for several risk factors, the odds ratio was not affected, but the confidence interval was wider and the p value for trend was less significant. Dietary and plasma levels of vitamin B6 and folate were lower in cases than in controls...Continue Reading

Citations

Feb 24, 2001·Clinical Cardiology·A U Chai, J Abrams
Apr 24, 2009·European Journal of Nutrition·Darío Pérez-ConesaGaspar Ros
Dec 21, 2000·Current Atherosclerosis Reports·W G Christen, P M Ridker
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·N S Key
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sevgi Yardim-AkaydinBolkan Simşek
Feb 20, 2004·The Journal of Nutritional Biochemistry·Stuart J MoatJonathan Goodfellow
May 1, 1997·Journal of the American Dietetic Association·R M Russell
Apr 1, 1996·The American Journal of Cardiology·W EgertonN Dudman
Jul 27, 2001·Atherosclerosis·W E van den BrandhofP Verhoef
Dec 23, 1998·Atherosclerosis·J B UbbinkW J Vermaak
Sep 16, 1999·Atherosclerosis·N JacobG Turpin
Jul 10, 1999·Journal of the American College of Cardiology·P AmbrosiR Luccioni
Jul 3, 1998·Gastroenterology Clinics of North America·J R Saltzman, R M Russell
May 5, 2001·Journal of Clinical Epidemiology·A de BreeD Kromhout
Jul 3, 2002·Nutrition·Sue-Joan ChanChen-Hsiang Shen
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanan H Hagar
Jul 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·I KutschkaA Haverich
Jan 1, 2012·Journal of Nutritional Science·Sigrunn HernesMargaretha Haugen
Apr 21, 2011·The Journal of Biological Chemistry·Arun KumarShantanu Sengupta
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Heike A BischoffWalter C Willett
Apr 1, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Farbod RaiszadehMarshall J Glesby
Dec 6, 2012·American Journal of Physiology. Endocrinology and Metabolism·Mei ZhaoJesse F Gregory
Jan 2, 2009·Stroke; a Journal of Cerebral Circulation·Howard N HodisUNKNOWN BVAIT Research Group
Mar 20, 2001·The Journal of Clinical Investigation·M A HofmannA M Schmidt
Oct 25, 2003·Lipids in Health and Disease·Nelva T de Gómez DummLuis A Touceda
Dec 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Joerg H HolsteinLutz Claes
Dec 3, 2003·The Tohoku Journal of Experimental Medicine·Belgin Süsleyici DumanHüsrev Hatemi
Sep 24, 2004·The Tohoku Journal of Experimental Medicine·Abdulkadir KocerMehmet Sargin
Oct 13, 2000·American Journal of Public Health·M J MedranoG López-Abente

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