PMID: 9194803Jun 15, 1997Paper

Homocysteine, oxidative stress, and vascular disease

Hospital Practice
G N WelchJoseph Loscalzo

Abstract

First recognized in patients with rare inborn errors of metabolism, the association of elevated plasma homocysteine concentrations with atherosclerosis and thrombosis now seems relevant to the general population as well. The mechanism of injury appears to involve oxidative damage to endothelial cells. Vitamin supplementation can normalize homocysteine levels and may lower the incidence of atherothrombotic vascular disease.

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