Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain

Proceedings of the National Academy of Sciences of the United States of America
H FujiwaraR S Geha

Abstract

The cytokines interleukin (IL)-4 and IL-13 play a critical role in inducing Cepsilon germline transcripts and IgE isotype switching in human B cells. The IL-4 receptor (IL-4R) in B cells is composed of two chains, the IL-4-binding IL-4Ralpha chain, which is shared with the IL-13R, and the IL-2Rgamma (gammac) chain, which is shared with IL-7R, IL-9R, and IL-15R. IL-4 induces Cepsilon germline transcripts and IgE isotype switching in B cells from patients with gammac chain deficiency. Induction of Cepsilon germline transcripts by IL-4 in B cells that lack the gammac chain may involve signaling via the IL-13R. Alternatively, the IL-4Ralpha chain may transduce intracellular signals that lead to Cepsilon gene transcription independently of its association with other chains. We show that ligand-induced homodimerization of chimeric surface receptors consisting of the extracellular and transmembrane domains of the erythropoietin receptor and of the intracellular domain of IL-4Ralpha induces Janus kinase 1 (Jak1) activation, STAT6 activation, and Cepsilon germline transcripts in human B cell line BJAB. Disruption of the Jak1-binding proline-rich Box1 region of IL-4Ralpha abolished signaling by this chimeric receptor. Furthermore, B cell...Continue Reading

References

Dec 1, 1992·Current Opinion in Immunology·D Vercelli, R S Geha
Apr 15, 1991·La Clinica terapeutica·F T Trojani
Aug 1, 1991·European Journal of Immunology·U MoebiusS C Meuer
Jan 1, 1991·Molecular Immunology·C A BergmannD R Kaplan
Sep 1, 1995·Clinical Immunology and Immunopathology·G de Saint BasileA Fischer
Aug 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D KaplanZ Yildirim
Jan 1, 1994·The Journal of Experimental Medicine·T DefranceP Ferrara
Sep 16, 1994·Science·J HouS L McKnight
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Y LaiM A Goldsmith
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonT A Willson
Apr 18, 1996·Nature·K TakedaS Akira
Jul 19, 1996·The Journal of Biological Chemistry·S V KotenkoS Pestka
Sep 27, 1996·The Journal of Biological Chemistry·W KammerK Friedrich
Feb 1, 1951·The Journal of Applied Psychology·G C MARTIN

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Citations

Feb 11, 2000·The Journal of Allergy and Clinical Immunology·L B Bacharier, R S Geha
Jul 13, 2000·Veterinary Immunology and Immunopathology·B J HartnettP J Felsburg
Oct 15, 2003·The Journal of Experimental Medicine·Frank BlaeserTalal A Chatila
Jun 8, 1999·Annual Review of Immunology·K NelmsW E Paul
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LuP B Rothman
Apr 28, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Waldemar WagnerJarosław Dastych
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R BaettaE Cattaneo
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·M H Heim
Oct 16, 2018·Frontiers in Immunology·Claire GorbyIgnacio Moraga
Apr 5, 2005·Cancer Research·Shaik Ohidar RahamanS Jaharul Haque
Jul 11, 2000·The Journal of Allergy and Clinical Immunology·K IzuharaJ M Hopkin
Jun 10, 1998·Biochemical and Biophysical Research Communications·N HaradaK Izuhara
Jan 24, 2006·Progress in Retinal and Eye Research·Naoki KumagaiTeruo Nishida
Nov 22, 2011·Biophysical Journal·Thomas WeidemannPetra Schwille

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