Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: histomorphometric analysis

Archives of Oral Biology
Maria das Graças Vilela-GoulartMônica Fernandes Gomes

Abstract

Oral mucositis is a frequent and significant side effect of chemotherapy and/or radiation therapy. The purpose of this study was to evaluate the effects of the homogenous amniotic membrane (HAM) as a biological dressing for oral mucositis induced by 5-fluorouracil (5-FU) in the labial fornix region of inferior incisors in rats. Sixty rats were divided into three groups: control (50% acetic acid), 5-FU (50% acetic acid and 5-fluorouracil-induced oral mucositis) and 5-FU+HAM (50% acetic acid and 5-fluorouracil-induced oral mucositis, and treated with HAM). Histological analyses were done 3, 7, 14 and 21 days after applying the acetic acid. HAM showed not only no signs of rejection as well as an excellent tissue adherence to the ulcerated surface. Histomorphometric analysis indicated a lower quantity of inflammatory cells in the 5-FU+HAM group in all periods when compared to the other groups and there was a statistically significant difference in the 3- and 7-day periods (P<0.001). The results of this study suggest that HAM was biocompatible with great adhesive power to the ulcerated surface, accelerated the healing process and exhibited anti-inflammatory activity. Further studies should be done to investigate the potential benefi...Continue Reading

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Citations

Jan 16, 2016·International Journal of Biomaterials·Akanksha GuptaKanu Jain
Jul 6, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Patricia Molina PratsPia Lopez-Jornet
Jun 20, 2014·Journal of Dental Research·C T VietB L Schmidt
Nov 7, 2019·Biochemistry and Biophysics Reports·Kamichika HayashiTakahiko Shibahara

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