Homogenous distribution of fast response action potentials in canine pulmonary vein sleeves: a contradictory report

International Journal of Cardiology
Tsui-Min WangHsiang-Ning Luk

Abstract

Pulmonary veins may serve as source of ectopic focus (or foci) in initiating atrial tachyarrhythmias in human beings. However, the animal model for such focal atrial fibrillation is still lacking and cellular mechanism for arrhythmias remains to be studied. Recently, a series of reports of cellular electrophysiological characterization of pulmonary vein sleeves demonstrated an extremely high incidence of automaticity (varied from 40 to 76%) and triggered activity (from 0 to 44%) in normal healthy control dogs and rabbits. The present study was therefore designed to re-investigate the cellular electrophysiological properties of canine pulmonary veins. Intracellular action potentials were characterized in pulmonary vein sleeves in 50 normal healthy dogs. Conventional glass microelectrode recording technique was used. Experiments were focused on the incidence of automaticity and triggered activity in pulmonary vein sleeve tissues. Surprisingly, our results showed that all pulmonary vein sleeves tissues in these dogs displayed fast-response action potentials under the well-controlled experimental condition (100%, n=50). No spontaneous pacemaking activities, early or delayed afterdepolarisations were observed (0%, n=50). No high-fre...Continue Reading

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Citations

Sep 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Akiko Shiroshita-TakeshitaStanley Nattel
Sep 3, 2005·International Journal of Cardiology·Tsui-Min WangChern-En Chiang
Dec 31, 2008·Journal of the Chinese Medical Association : JCMA·Hsiang-Ning LukYuan-Ji Day
Sep 8, 2010·Cell Calcium·Sunil Jit R J LoganthaRobert M Drummond
Jul 25, 2009·Pharmacology & Therapeutics·Marisa Chard, Reza Tabrizchi
Oct 10, 2007·Progress in Biophysics and Molecular Biology·Chang Ahn SeolChae Hun Leem
Mar 6, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Andrew L Wit, Penelope A Boyden
Aug 2, 2003·Journal of Cardiovascular Electrophysiology·Shih-Ann Chen, Hung-I Yeh
Oct 1, 2005·Progress in Cardiovascular Diseases·Stanley NattelLéna Rivard
Jan 1, 2014·Pacing and Clinical Electrophysiology : PACE·Shaohua ZhengYinglong Hou
Apr 13, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Chae Hun LeemYung E Earm
Dec 11, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Elizabeth M CherryFlavio H Fenton
Jun 26, 2003·Pacing and Clinical Electrophysiology : PACE·Shih-Ann ChenCheng-I Lin
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pierre CoutuStanley Nattel
Jun 21, 2018·Pharmacological Reviews·David CalvoJosé Jalife
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Nicolas DoisneIan Findlay

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