PMID: 14025531May 3, 1963

Homograft tolerance in mice: use of urethan and sublethal irradiation

W E Davis, L J Cole


Adult mice [CBA/J (H-2(k))], which received either a single sublethal dose of x-radiation (500 rad) or urethan plus 500 rad, were given intravenous injections of C3H/HeJ (H-2(k)) spleen or bone marrow cells (18 to 42 x 10(6) cells per mouse) or both, for 3 days. C3H/HeJ tail-skin homografts were retained (over 130 days) by these mice, whereas BALB/cJ (H-2(d)) homografts all were rejected within 33 days. Similarly irradiated or urethan-treated controls (or controls treated with a combination of both), which did not receive C3H cells, rejected both homografts. Specific homograft tolerance is induced in adult mice by this procedure.


Sep 10, 1964·The New England Journal of Medicine·P S RUSSELL, A P MONACO

Related Concepts

Intravenous Injections
CBA/J Mouse
Effects of Radiation
Spleen Tissue
Bone Marrow Cells
C3H/HeJ Mouse
BALB/cJ Mouse

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