Homolateral cerebrocortical changes in neuropeptide and receptor expression after minimal cortical infarction

Neuroscience
L Van BreeJ J Vanderhaeghen

Abstract

A cortical infarct of 2 mm diameter was obtained in the parietal cortex after a craniotomy, disruption of the dura mater and topical application of 3 M KCl. It has been shown previously that the presence of a small cortical infarct induces an increase in immediate early gene messenger RNA expression followed by an increase in neuropeptide and glutamic acid decarboxylase messenger RNA expression. Glutamate, acting at N-methyl-D-aspartate receptors, is held responsible for these changes, since they are blocked by pretreatment with dizocilpine. In the present study, we have analysed the consequences of the dramatic changes in messenger RNA expression on the level of immediate early gene products c-fos and zif 268, and on that of neuropeptides by using immunohistochemistry. After just 1 h, an increase in c-fos- and zif 268-like immunoreactivity is observed in the entire cortical hemisphere homolateral to the infarct, and is no longer detected after 6 h. An increase in cholecystokinin octapeptide-, substance P-, neuropeptide Y- and somatostatin-like immunoreactivity is observed in the entire cortical hemisphere homolateral to the infarct after three days, and is no longer detected after 30 days. To investigate if these dramatic incr...Continue Reading

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P RobberechtJ J Vanderhaeghen
Jun 1, 1975·Endocrinology·M BrownsteinJ S Kizer
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A WankA de Weerth
Jun 1, 1991·Brain Research. Molecular Brain Research·C OlenikD K Meyer
Dec 17, 1991·Brain Research. Developmental Brain Research·J A Del RioI Ferrer
Oct 1, 1990·Molecular and Cellular Biology·C AbateT Curran
Apr 1, 1990·Brain Research. Molecular Brain Research·N H Zawia, S C Bondy
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, F Bengtsson
Jan 1, 1986·Brain Research·T H MoranP R McHugh
May 20, 1988·Science·F J RauscherB R Franza
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Sep 1, 1987·Peptides·F Lotstra, J J Vanderhaeghen
Mar 1, 1988·Journal of Neurochemistry·L WennogleB Petrack
Aug 26, 1983·Science·Y S AllenJ M Polak
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R B Innis, S H Snyder
Jan 1, 1981·Peptides·J J VanderhaeghenP Verbanck
Jan 28, 1983·European Journal of Pharmacology·P GaudreauC B Pert
Jan 1, 1984·Cell and Tissue Research·G PelletierJ Cote
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J J VanderhaeghenC Gilles

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Citations

Jun 25, 2016·International Journal of Molecular Sciences·Leonardo LorenteMariano Hernández
Jan 29, 2020·Journal of Critical Care·Leonardo LorenteVictor García-Marín

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