PMID: 11931237Apr 5, 2002Paper

Homologous chromosome associations and nuclear order in meiotic and mitotically dividing cells of budding yeast

Advances in Genetics
Sean M Burgess

Abstract

This chapter discusses the relationship between nuclear order and the association of homologous DNA sequences in the budding yeast, Saccharomyces cerevisiae. Homologous chromosomes functionally interact with one another to repair DNA double-strand breaks (DSBs) introduced either environmentally (e.g., by gamma-irradiation) or deliberately by the cell (e. g., during meiosis). DNA homology recognition in these instances often involves the (RecA) homolog RAD51 and/or the related gene, DMC1. Evidence for interactions between homologous chromosomes occurring independent of DSB formation and (RecA) homolog function has also been described in meiotic, premeiotic, and mitotically dividing cells of yeast. These interactions presumably depend upon DNA homology but the molecular details of such associations are poorly understood. Both DSB-dependent and -independent homolog associations may be facilitated by the nonrandom organization of chromosomes in the nucleus, including centromere and telomere clustering, which are also discussed.

Citations

Oct 12, 2004·Annual Review of Cell and Developmental Biology·Scott L Page, R Scott Hawley
Mar 24, 2006·Chromosoma·Mónica P Colaiácovo
Sep 3, 2010·Journal of Molecular Recognition : JMR·A G Cherstvy
Mar 26, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Valeriya GaysinskayaAlex Bortvin
Feb 19, 2010·Nature Reviews. Molecular Cell Biology·Mariko SasakiScott Keeney
Mar 25, 2011·Physical Chemistry Chemical Physics : PCCP·A G Cherstvy
Mar 9, 2005·Cytogenetic and Genome Research·S P SosnikhinaY F Bogdanov
Sep 17, 2009·Nature Reviews. Microbiology·Allon WeinerAbraham Minsky
Jul 29, 2004·DNA Repair·Christine RichardsonTej K Pandita
Aug 19, 2007·Differentiation; Research in Biological Diversity·Harry Scherthan, Edgar Trelles-Sticken
Aug 9, 2003·Science·Scott L Page, R Scott Hawley

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