PMID: 9531544May 16, 1998Paper

Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations

The Journal of Cell Biology
J C FungJ W Sedat

Abstract

The dynamics by which homologous chromosomes pair is currently unknown. Here, we use fluorescence in situ hybridization in combination with three-dimensional optical microscopy to show that homologous pairing of the somatic chromosome arm 2L in Drosophila occurs by independent initiation of pairing at discrete loci rather than by a processive zippering of sites along the length of chromosome. By evaluating the pairing frequencies of 11 loci on chromosome arm 2L over several timepoints during Drosophila embryonic development, we show that all 11 loci are paired very early in Drosophila development, within 13 h after egg deposition. To elucidate whether such pairing occurs by directed or undirected motion, we analyzed the pairing kinetics of histone loci during nuclear cycle 14. By measuring changes of nuclear length and correlating these changes with progression of time during cycle 14, we were able to express the pairing frequency and distance between homologous loci as a function of time. Comparing the experimentally determined dynamics of pairing to simulations based on previously proposed models of pairing motion, we show that the observed pairing kinetics are most consistent with a constrained random walk model and not cons...Continue Reading

References

Mar 21, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M D Bennett
Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·R P LiftonD S Hogness
Feb 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G J Gorbsky
Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·N KlecknerD K Bishop
Dec 1, 1991·The Plant Cell·J BollmannE S Coen
Feb 1, 1991·Experimental Cell Research·T Haaf, M Schmid
Apr 19, 1991·Cell·K D Tartof, S Henikoff
Dec 1, 1990·Genome Génome / Conseil National De Recherches Canada·J Loidl
Jan 1, 1989·Methods in Cell Biology·D A AgardJ W Sedat
Apr 15, 1983·Experimental Cell Research·D H WilliamsonG Simchen
Sep 21, 1995·Journal of Theoretical Biology·D DorningerJ Loidl
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·G S Roeder
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·N Kleckner, B M Weiner
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·D L HartlE R Lozovskaya
Apr 8, 1994·Science·Y ChikashigeY Hiraoka
Feb 1, 1993·The Journal of Cell Biology·Y HiraokaJ W Sedat
May 3, 1996·Science·J M LaSalle, M Lalande
Jun 27, 1996·Nature·A S Goldsborough, T B Kornberg
Jul 12, 1996·Cell·R Aramayo, R L Metzenberg
Feb 21, 1998·Current Biology : CB·W F MarshallJ W Sedat

❮ Previous
Next ❯

Citations

Feb 10, 2009·Chromosoma·Claudia HeppergerSteffen Dietzel
May 25, 2007·Molecular Genetics and Genomics : MGG·Veit SchubertIngo Schubert
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Cornelia FritschDonna J Arndt-Jovin
Jun 16, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Veit SchubertAndreas Houben
May 18, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Yukiko M Yamashita
Mar 17, 2004·Biochimica Et Biophysica Acta·Bruce D McKee
Oct 12, 2000·Biophysical Chemistry·J A Subirana, N G Abrescia
May 7, 2013·Nature·Swathi Yadlapalli, Yukiko M Yamashita
Nov 5, 2008·Nature Reviews. Genetics·Gloria A Brar, Angelika Amon
Nov 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·C DanilowiczM Prentiss
Jun 12, 2002·Molecular Biology of the Cell·Joseph Ostashevsky
Feb 24, 2006·Molecular Biology of the Cell·Julio VazquezJohn W Sedat
Apr 20, 2007·Molecular Biology of the Cell·Anne E WhiteRobert J Duronio
Jul 1, 1999·Genes & Development·S M BurgessB M Weiner
May 15, 2012·Science·Abby F Dernburg
Dec 17, 2004·Molecular and Cellular Biology·Brian T SageAmy K Csink
Oct 18, 2005·Molecular and Cellular Biology·Elena KravchenkoMikhail Savitsky
Jul 4, 2008·Annual Review of Cell and Developmental Biology·Needhi Bhalla, Abby F Dernburg
Feb 3, 1999·Annual Review of Genetics·D Zickler, N Kleckner
Aug 30, 2008·PLoS Computational Biology·Angelo Rosa, Ralf Everaers
Jun 2, 2012·PLoS Genetics·Giovanni Bosco
Jun 10, 2005·Genetics·Alistair B CoulthardArthur J Hilliker
Sep 25, 2007·Genetics·Benjamin R WilliamsC-Ting Wu
Jun 1, 2012·Genetics·Jack R BatemanMelissa N Locke
Jun 1, 2012·Genetics·Frauke Greil, Kami Ahmad
Apr 1, 2010·Epigenomics·Shigeki NagaiSusan M Gasser
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·A S Goldman, M Lichten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.