PMID: 5849234Oct 1, 1965Paper

Homologous disease in the adult rat, a model for autoimmune disease. II. Findings in the joints, heart, and other tissues

The Journal of Experimental Medicine
P STASTNYM ZIFF

Abstract

Polyarthritis and cardiac lesions have been observed in the adult rat with homologous disease. Changes in the lymphoid tissue and kidney have also been noted. A migratory polyarthritis occurred in over half of the affected animals, and cardiac involvement of varying intensity was present in all. Histologically, the arthritis was characterized by a mononuclear synovial inflammatory reaction. In the heart, the valves and myocardium demonstrated a similar type of response. Cultures of involved joints and hearts for pyogens and pleuropneumonia-like organisms were negative. The lymphoid tissues showed progressive changes in three stages: (a) disappearance of follicles; (b) increase in plasma-like cells and histiocytes; and (c) fibrosis. The second stage tended to coincide with the development of the polyarthritis. The kidney showed mild interstitial mononuclear infiltration. The pathologic changes described appear to be a consequence of reaction between foreign immunologically competent cells and host antigens, but the possibility that these lesions represent a response to antigens derived from unknown infectious agents is, however, not ruled out.

References

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Citations

Feb 25, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·E Gleichmann, H Gleichmann
Oct 1, 1968·The Journal of Experimental Medicine·R M LewisR S Schwartz
Sep 1, 1970·The Journal of Experimental Medicine·M Y ArmstrongR S Schwartz
Jun 28, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carol M Artlett
Aug 14, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Carol M ArtlettJ Bruce Smith
Sep 1, 1985·Clinical Immunology and Immunopathology·J P Reeves, A D Steinberg
Apr 1, 1974·Cancer·F J Paradinas, K M Harrison
Oct 15, 1974·International Journal of Cancer. Journal International Du Cancer·N KuzumakiH Kobayashi

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