Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test

Molecular Cancer Research : MCR
Brennan DeckerElaine A Ostrander

Abstract

Targeted cancer therapies offer great clinical promise, but treatment resistance is common, and basic research aimed at overcoming this challenge is limited by reduced genomic and biologic complexity in artificially induced rodent tumors compared with their human counterparts. Animal models that more faithfully recapitulate genotype-specific human pathology could improve the predictive value of these investigations. Here, a newly identified animal model for oncogenic BRAF-driven cancers is described. With 20,000 new cases in the United States each year, canine invasive transitional cell carcinoma of the bladder (InvTCC) is a common, naturally occurring malignancy that shares significant histologic, biologic, and clinical phenotypes with human muscle invasive bladder cancer. In order to identify somatic drivers of canine InvTCC, the complete transcriptome for multiple tumors was determined by RNAseq. All tumors harbored a somatic mutation that is homologous to the human BRAF(V600E) mutation, and an identical mutation was present in 87% of 62 additional canine InvTCC tumors. The mutation was also detectable in the urine sediments of all dogs tested with mutation-positive tumors. Functional experiments suggest that, like human tum...Continue Reading

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·T J JónasdóttirF Lingaas
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jun 21, 2002·The Journal of Small Animal Practice·J M DobsonJ L N Wood
Apr 29, 2004·Journal of the American Veterinary Medical Association·Lawrence T GlickmanMarcia H Dawson
May 25, 2004·Science·Heidi G ParkerLeonid Kruglyak
Oct 19, 2004·Cancer Cell·Mathew J Garnett, Richard Marais
Apr 19, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Suzanne ShellyCheryl A London
Oct 28, 2005·The Journal of Heredity·A RichterJ Bullerdiek
Nov 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Edouard Cadieu, Elaine A Ostrander
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·James TsaiGideon Bollag
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Matthew Breen, Jaime F Modiano
Apr 23, 2008·Current Protocols in Human Genetics·S A ForbesM R Stratton
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Nov 5, 2010·Annual Review of Genetics·Heidi G ParkerElaine A Ostrander
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
May 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Abigail L ShearinElaine A Ostrander
Apr 1, 2011·Clinical Investigation·Elizabeth A GuancialJonathan E Rosenberg
Jul 24, 2012·Cell·Eran HodisLynda Chin
Sep 12, 2012·Nature Reviews. Clinical Oncology·Eric A CollissonJoe W Gray
Oct 26, 2012·Hematology/oncology and Stem Cell Therapy·George Orphanos, Panteleimon Kountourakis
Nov 10, 2012·International Journal of Clinical Practice·T R L Griffiths, UNKNOWN Action on Bladder Cancer
Feb 19, 2013·Critical Reviews in Oncology/hematology·Mario Mandalà, Christiane Voit
Jun 12, 2013·Veterinary and Comparative Oncology·J S FowlesD L Gustafson
Jul 31, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gopa IyerDavid B Solit
Nov 5, 2013·The Journal of Clinical Endocrinology and Metabolism·Bert DelvouxAndrea Romano
Nov 10, 2013·Nature Medicine·Piro LitoDavid B Solit
Dec 24, 2013·Trends in Pharmacological Sciences·Min HuangMeiyu Geng

❮ Previous
Next ❯

Citations

Nov 14, 2015·Annual Review of Animal Biosciences·Heather L GardnerCheryl A London
Feb 5, 2016·Science Translational Medicine·Amy K LeBlancChand Khanna
Apr 14, 2016·Stem Cells·Andrew M Hoffman, Steven W Dow
Oct 8, 2016·Veterinary and Comparative Oncology·H Mochizuki, M Breen
Jan 5, 2017·Genes, Chromosomes & Cancer·Stephen A RamseyShay Bracha
Sep 26, 2017·Nature Reviews. Genetics·Elaine A OstranderBrian W Davis
Nov 13, 2018·Annual Review of Animal Biosciences·Elaine A OstranderJacquelyn M Evans
Apr 23, 2019·Journal of Veterinary Internal Medicine·Katherine R LuethckeLauren A Trepanier
May 3, 2019·Molecular Pharmacology·Kathryn E CroniseDawn L Duval
Nov 13, 2019·Nucleic Acids Research·Jennifer R SmithMary E Shimoyama
Mar 17, 2020·Expert Opinion on Drug Discovery·Michael D Lucroy, Mark A Suckow
Apr 5, 2017·Aging·Michael J ThompsonMatteo Pellegrini
Nov 30, 2018·Veterinary Sciences·Maureen A GriffinRobert B Rebhun
Jan 20, 2016·Veterinary Sciences·Nikolaos Dervisis, Shawna Klahn
Dec 6, 2019·Frontiers in Oncology·Douglas H Thamm
Nov 20, 2016·BMC Veterinary Research·Sarah B RippyCheryl A London
Sep 17, 2020·Nature Reviews. Cancer·Amy K LeBlanc, Christina N Mazcko
Aug 24, 2015·Veterinary Sciences·Hiroyuki Mochizuki, Matthew Breen
Jun 9, 2019·Molecular Cancer Therapeutics·Sunetra DasDawn L Duval
Feb 13, 2020·Cancer Cell·Samirkumar B AminRoel G W Verhaak
Mar 12, 2021·Advanced Drug Delivery Reviews·Lisa A Mestrinho, Ricardo R Santos
Apr 2, 2021·PLoS Genetics·Benoît HédanCatherine André
May 12, 2021·The Journal of Small Animal Practice·A GuillenD R Killick
May 23, 2021·Veterinary and Comparative Oncology·Kathryn E CroniseDawn L Duval

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.