Homologous recombination in bovine pestiviruses. Phylogenetic and statistic evidence

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Leandro Roberto Jones, E L Weber

Abstract

Bovine pestiviruses (Bovine Viral Diarrea Virus 1 (BVDV 1) and Bovine Viral Diarrea Virus 2 (BVDV 2)) belong to the genus Pestivirus (Flaviviridae), which is composed of positive stranded RNA viruses causing significant economic losses world-wide. We used phylogenetic and bootstrap analyses to systematically scan alignments of previously sequenced genomes in order to explore further the evolutionary mechanisms responsible for variation in the virus. Previously published data suggested that homologous crossover might be one of the mechanisms responsible for the genomic rearrangements observed in cytopathic (cp) strains of bovine pestiviruses. Nevertheless, homologous recombination involves not just homologous crossovers, but also replacement of a homologous region of the acceptor RNA. Furthermore, cytopathic strains represent dead paths in evolution, since they are isolated exclusively from the fatal cases of mucosal disease. Herein, we report evidence of homologous inter-genotype recombination in the genome of a non-cytopathic (ncp) strain of Bovine Viral Diarrea Virus 1, the type species of the genus Pestivirus. We also show that intra-genotype homologous recombination might be a common phenomenon in both species of Pestivirus...Continue Reading

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Citations

Dec 4, 2013·Research in Veterinary Science·A PecoraA Wigdorovitz
Nov 11, 2014·Annual Review of Animal Biosciences·Matthias Schweizer, Ernst Peterhans
Feb 25, 2006·Journal of Virological Methods·Leandro R JonesE Laura Weber
Jan 7, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Matheus Nunes WeberCláudio Wageck Canal
Jul 13, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Aspen M WorkmanCarol G Chitko-McKown
Oct 27, 2017·Nucleic Acids Research·Margaret M WillcocksNicolas Locker
Oct 24, 2018·Animal Health Research Reviews·Mauro Larghi
Aug 31, 2007·Veterinary Research·Bernard CouvreurPierre Kerkhofs
Oct 13, 2006·The Australian Journal of Rural Health·Karen Larsen, David Perkins
Jan 13, 2018·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Lalitha PeddireddiIvan Leyva-Baca

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