Homologous recombination in human iPS and ES cells for use in gene correction therapy

Drug Discovery Today
Manabu Nakayama

Abstract

The emergence of induced pluripotent stem (iPS) cell technology has shifted gene correction therapy toward reality. Crucial issues are ensuring the safety of using iPS cell technology in patients and discovering how best to transfer genetically manipulated iPS cells back into patients. One key issue that has hindered progress of gene correction therapy, however, is the inability to achieve efficient homologous recombination in human iPS cells. This review focuses on recently developed technologies that aim to improve homologous recombination in human embryonic stem cells and on their application to iPS cells.

Citations

Jan 13, 2011·Archives of Toxicology·Anna M Wobus, Peter Löser
Sep 16, 2011·Regenerative Medicine·Bahram ValamehrHong Wu
Oct 10, 2013·EMBO Molecular Medicine·Kerstin B KaufmannManuel Grez
Jun 17, 2011·Journal of Immunotoxicology·Jeffrey S Kennedy, David A Lawrence
Mar 29, 2011·The Journal of Allergy and Clinical Immunology·Itai M Pessach, Luigi D Notarangelo
Aug 21, 2012·Annals of the New York Academy of Sciences·Dirk W van Bekkum, Harald M M Mikkers
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