Nov 4, 2018

Homologous Recombination as an Evolutionary Force in African Swine Fever Viruses

BioRxiv : the Preprint Server for Biology
Zhaozhong ZhuChaoting Xiao

Abstract

Recent outbreaks of African swine fever virus (ASFV) in China severely influenced the swine industry of the country. Currently, there is no effective vaccine or drugs against ASFVs. How to effectively control the virus is challenging. In this study, we have analyzed all the publicly available ASFV genomes and demonstrated that there was a large genetic diversity of ASFV genomes. Interestingly, the genetic diversity was mainly caused by extensive genomic insertions and/or deletions (indels) instead of the point mutations. The genomic diversity of the virus resulted in proteome diversity. Over 250 types of proteins were inferred from the ASFV genomes, among which only 144 were observed in all analyzed viruses. Further analyses showed that the homologous recombination may contribute much to the indels, as supported by significant associations between the occurrence of extensive recombination events and the indels in the ASFV genomes. Repeated elements of dozens of nucleotides in length were observed to widely distribute and cluster in the adjacent positions of ASFV genomes, which may facilitate the occurrence of homologous recombination. Moreover, two enzymes, which were possibly related to the homologous recombination, i.e., a La...Continue Reading

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Mentioned in this Paper

Study
Virus
Genome
Enzymes, antithrombotic
Vaccines
Genomic Stability
Recombination, Genetic
Gene Deletion
Recombinase
Etiology

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