Homologous regions shared by adhesin genes of Mycoplasma pneumoniae and Mycoplasma genitalium

Microbial Pathogenesis
S F DalloJ B Baseman

Abstract

A lambda gt11 library of Mycoplasma genitalium genomic DNA was generated, and clones were identified using a pool of monoclonal antibodies directed against different epitopes of the 140 kDa adhesin protein. Because the 140 kDa protein of M. genitalium and the 170 kDa P1 adhesin of M. pneumoniae share biological properties such as a tip-associated location, cytadherence function and immunologic crossreactivity, we performed Southern blot analysis using these cloned partial 140 kDa gene fragments and 14 subclones that span the P1 structural gene of M. pneumoniae. Homologous regions of the two genes were identified.

References

Feb 1, 1988·The Journal of Experimental Medicine·S F DalloJ B Baseman
Aug 1, 1987·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·W BredtE Jacobs
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R A Young, R W Davis
Feb 1, 1983·The Journal of Experimental Medicine·D K LeithJ B Baseman

❮ Previous
Next ❯

Citations

Apr 6, 2006·Journal of Bacteriology·Oxana MusatovovaJoel B Baseman
Jun 6, 2003·Molecular Microbiology·René A AlvarezJoel B Baseman
Aug 1, 1990·Journal of Bacteriology·C J Su, J B Baseman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.