Homologous up-regulation of vitamin D receptors is tissue specific in the rat

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
R C GensureM R Walters

Abstract

1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptors (VDR) are expressed in multiple tissues within the body. VDR levels are increased by 1,25(OH)2D3 in intestine and kidney and in numerous cell models. The ability of 1,25(OH)2D3 to affect VDR levels in other target tissues in vivo was studied by assessing VDR levels by the 3H-1,25(OH)2D3 binding assay under varied physiological conditions in the rat. When compared with vitamin D-deficient (-D) controls, rats raised on a normal vitamin D-sufficient (+D) diet showed elevated VDR levels in kidney (391 +/- 53 vs. 913 +/- 76 fmol/g of tissue;p < 0.05), but not in testis, heart, or lung. Up-regulation of the VDR also occurred in kidney of +D rats 1 day after a single 100-ng dose of 1,25(OH)2D3 (454 +/- 43 vs. 746 +/- 113 fmol/mg of DNA; p < 0.05), but no changes were seen in intestine, testis, or lung. Because 1,25(OH)2D3-induced hypercalcemia may independently affect VDR regulation, 1,25(OH)2D3 was infused into -D rats, and normocalcemia was maintained by reduced dietary calcium intake. In this model, the renal VDR was again up-regulated (446 +/- 115 vs. 778 +/- 58 fmol/mg of DNA; p < 0.05), but VDR levels in testis and lung were unaffected. Scatchard analysis and tests of 1,25(OH)2D3 ...Continue Reading

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Citations

May 29, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Martin Blomberg Jensen
May 14, 2009·Journal of Nutritional Science and Vitaminology·Handan MertNihat Mert
Mar 28, 2017·Molecular and Cellular Endocrinology·Mette LorenzenMartin Blomberg Jensen
Jan 15, 2014·Nature Reviews. Endocrinology·Martin Blomberg Jensen
Jul 2, 2017·Reviews in Endocrine & Metabolic Disorders·Cristina de AngelisRosario Pivonello
Dec 12, 2001·American Journal of Physiology. Renal Physiology·Emmanuel K O Siaw, Marian R Walters
Mar 7, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Emma L WatsonAlice C Smith
Feb 17, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Danusa MenegazLaura P Zanello

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