Homologous upregulation of human arterial alpha-adrenergic responses by guanadrel

The Journal of Clinical Investigation
R V Hogikyan, M A Supiano

Abstract

The purpose of this study was to test the hypothesis that there is homologous upregulation of arterial alpha-adrenergic responsiveness during suppression of sympathetic nervous system (SNS) activity in humans. 10 subjects (19-28 yr) were studied during placebo and when SNS activity was suppressed by guanadrel. Changes in forearm blood flow (FABF) mediated by the intraarterial infusion of norepinephrine (NE), angiotensin II (AII), and phentolamine were measured by plethysmography. During guanadrel compared with placebo, plasma NE levels (1.28 +/- 0.09-0.85 +/- 0.06 nM; P = 0.0001) and the extra vascular NE release rate derived from [3H]NE kinetics were lower (7.1 +/- 0.7-4.0 +/- 0.2 nmol/min per m2; P = 0.0004), suggesting suppression of SNS activity. During guanadrel, there was increased sensitivity in the FABF response to NE (analysis of variance P = 0.03). In contrast, there was no difference in the FABF response to AII (analysis of variance P = 0.81), suggesting that the upregulation observed to NE was homologous. The increase in FABF during phentolamine was similar during guanadrel compared with placebo (guanadrel: 141 +/- 37 vs. placebo; 187 +/- 27% increase; P = 0.33), suggesting that there was at least partial compensati...Continue Reading

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Citations

Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·D M Lipnicki, P D Drummond
Oct 1, 2013·European Journal of Applied Physiology·J Andrew Taylor, Can Ozan Tan
Apr 17, 1999·Metabolism: Clinical and Experimental·R V HogikyanM A Supiano
Nov 22, 1997·Hypertension·J JordanD Robertson
Sep 10, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Chester A RayJonathan S Cook
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·P H RatzR W Barbee
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·P Michael GrossmanMark R Starling
Mar 16, 2002·Journal of Applied Physiology·Michael D BrownMark A Supiano

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