Homologs of mitochondrial transcription factor B, sparsely distributed within the eukaryotic radiation, are likely derived from the dimethyladenosine methyltransferase of the mitochondrial endosymbiont

Molecular Biology and Evolution
Timothy E Shutt, Michael W Gray

Abstract

Mitochondrial transcription factor B (mtTFB), an essential component in regulating the expression of mitochondrial DNA-encoded genes in both yeast and humans, is a dimethyladenosine methyltransferase (DMT) that has acquired a secondary role in mitochondrial transcription. So far, mtTFB has only been well studied in Opisthokonta (metazoan animals and fungi). Here we investigate the phylogenetic distribution of mtTFB homologs throughout the domain Eucarya, documenting the first examples of this protein outside of the opisthokonts. Surprisingly, we identified putative mtTFB homologs only in amoebozoan protists and trypanosomatids. Phylogenetic analysis together with conservation of intron positions in amoebozoan and human genes supports the grouping of the putative mtTFB homologs as a distinct clade. Phylogenetic analysis further demonstrates that the mtTFB is most likely derived from the DMT of the mitochondrial endosymbiont.

References

Sep 25, 1975·Journal of Molecular Biology·J KlootwijkL A Grivell
Mar 11, 1992·Nucleic Acids Research·B Xu, D A Clayton
Mar 5, 1999·Science·M W GrayB F Lang
Feb 19, 2000·Current Opinion in Structural Biology·G M Cheetham, T A Steitz
Sep 22, 2001·Protein Science : a Publication of the Protein Society·F D SchubotB C Wang
Feb 23, 2002·The Journal of Biological Chemistry·Jayleen GramsStephen L Hajduk
Jun 18, 2002·Nature Genetics·Maria FalkenbergClaes M Gustafsson
Dec 24, 2002·Nature Genetics·Bonnie L Seidel-RogolGerald S Shadel
Jun 26, 2003·Nucleic Acids Research·Ramu ChennaJulie D Thompson
Sep 2, 2003·Molecular Biology and Evolution·José F FahrniJan Pawlowski
Dec 3, 2003·Trends in Genetics : TIG·Gertraud BurgerB Franz Lang
May 12, 2004·Journal of Molecular Biology·Heather C O'FarrellJason P Rife
Sep 3, 2004·Current Biology : CB·Alastair G B Simpson, Andrew J Roger
Jul 16, 2005·Science·Alasdair C IvensPeter J Myler
Aug 27, 2005·Nature·Thomas A Richards, Thomas Cavalier-Smith
Sep 7, 2005·Trends in Cell Biology·Sally A Mackenzie
May 17, 2006·Trends in Ecology & Evolution·Patrick J KeelingMichael W Gray

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Citations

Oct 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yulia V SurovtsevaGerald S Shadel
Dec 14, 2011·Genome Biology and Evolution·Małgorzata WojtkowskaWojciech Makałowski
Jan 11, 2013·Nucleic Acids Research·Yulia V Surovtseva, Gerald S Shadel
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adrian C BarbrookSarah J Tarr
May 12, 2009·Molekuliarnaia biologiia·M Iu SologubD E Temiakov
Jun 19, 2009·BMC Evolutionary Biology·Yu-Juan ZhangJian-Fan Wen
Oct 31, 2008·BMC Research Notes·Heather C O'FarrellJason P Rife
Jun 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Timothy E ShuttGerald S Shadel
May 25, 2011·The Journal of Cell Biology·Chan Bae Park, Nils-Göran Larsson
Feb 13, 2007·Trends in Biochemical Sciences·Jordi Asin-Cayuela, Claes M Gustafsson
Jun 15, 2010·Environmental and Molecular Mutagenesis·Timothy E Shutt, Gerald S Shadel
Nov 26, 2009·The Plant Journal : for Cell and Molecular Biology·Uwe RichterThomas Börner
May 7, 2008·The American Journal of Pathology·Gerald S Shadel
Aug 5, 2014·Cell Metabolism·B Martin Hällberg, Nils-Göran Larsson
May 29, 2015·Journal of Inherited Metabolic Disease·Lindsey Van HauteMichal Minczuk
Dec 26, 2006·Molecular Cell·Nicholas D BonawitzGerald S Shadel
Mar 30, 2016·Annual Review of Biochemistry·Claes M GustafssonNils-Göran Larsson
May 9, 2019·International Journal of Molecular Sciences·Arianna Barchiesi, Carlo Vascotto
Sep 17, 2019·Biochemistry. Biokhimii︠a︡·L A Zinovkina

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