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Homology- and coevolution-consistent structural models of bacterial copper-tolerance protein CopM support a 'metal sponge' function and suggest regions for metal-dependent protein-protein interactions

bioRxiv

Jan 16, 2015

Luciano A. Abriata

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Abstract

Abstract. Copper is essential for life but toxic, therefore all organisms control tightly its intracellular abundance. Bacteria have indeed whole operons devoted to copper resistance, with genes that code for efflux pumps, oxidases, etc. Recently, the CopM protein of the CopMRS operon w...read more

Mentioned in this Paper

Cell Secretion
Operon
Helix (Snails)
Radiographic Imaging Procedure
Structure of Lumen of Body System
Homologous Gene
Multidrug Efflux Pump Activity
Resistance Process
Synechocystis
Oxidase
5
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  • Homology- and coevolution-consistent structural models of bacterial copper-tolerance protein CopM support a 'metal sponge' function and suggest regions for metal-dependent protein-protein interactions

    bioRxiv

    Jan 16, 2015

    Luciano A. Abriata

    PMID: 990013581

    DOI: 10.1101/013581

    Abstract

    Abstract. Copper is essential for life but toxic, therefore all organisms control tightly its intracellular abundance. Bacteria have indeed whole operons devoted to copper resistance, with genes that code for efflux pumps, oxidases, etc. Recently, the CopM protein of the CopMRS operon w...read more

    Mentioned in this Paper

    Cell Secretion
    Operon
    Helix (Snails)
    Radiographic Imaging Procedure
    Structure of Lumen of Body System
    5

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