Homology and homocracy revisited: gene expression patterns and hypotheses of homology

Development Genes and Evolution
Mats E Svensson

Abstract

Homocracy, a term referring to shared regulatory gene expression patterns between organs in different animals, was introduced recently in order to prevent inappropriate inference of organ homology based on gene expression data. Non-homologous structures expressing homologous genes, and homologous structures expressing non-homologous genes illustrate that gene expression data is not sufficient on its own to identify morphological homology. However, gene expression data might be useful in testing hypotheses of organ homology, because parsimony can be applied on changes in the relation between expression of orthologous regulatory genes and the formation of homologous organs. A method of testing organ homology hypotheses with respect to change in regulatory gene expression required within a particular phylogenetic context is presented.

Citations

May 31, 2006·Development Genes and Evolution·Ronald A Jenner
Aug 15, 2012·Theory in Biosciences = Theorie in Den Biowissenschaften·Geoffrey Guinard
Oct 19, 2006·Theory in Biosciences = Theorie in Den Biowissenschaften·Günter Theissen
Oct 19, 2006·Theory in Biosciences = Theorie in Den Biowissenschaften·Rolf Rutishauser, Philip Moline
Oct 19, 2006·Theory in Biosciences = Theorie in Den Biowissenschaften·Günter Theissen
Feb 25, 2015·Developmental Cell·Volker Hartenstein, Angelika Stollewerk
Nov 11, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Graham E Budd

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