Homology of E2 gene in 8 child-mother pairs infected with hepatitis C virus

The Tohoku Journal of Experimental Medicine
R LiY Wada

Abstract

The frequency of genetic homology of hepatitis C virus (HCV) E2 gene in 8 child-mother pairs was investigated. The route of HCV infection of all children suggested mother-to-child infection by their past history. In this study, we analyzed at least 5 complementary DNA (cDNA) clones for each case. In 6 of the 8 (75%) child-mother pairs, for the region between hypervariable region (HVR)-1 and HVR-2, the similarity of the nucleotide sequence of all 5 cDNA clones between each child and the mother was higher than that between the child and the other children, the other mothers and the sequences from GenBank. One of the 8 (13%) child-mother pairs showed a great similarity in parts of all cDNA clones. This was also confirmed by phylogenetic analyses of the sequences of cDNA clones from families and that from GenBank. These results suggested that the homology search of nucleotide sequence of this region was useful to confirm mother-to-child transmission of HCV.

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Citations

Aug 13, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tokio SugiuraNorihisa Koyama
Feb 15, 2001·Virus Research·K SugiyamaT Yokoyama
Sep 24, 1998·Acta Paediatrica Japonica; Overseas Edition·K SugiyamaS Kajiura
Aug 24, 1999·The Tohoku Journal of Experimental Medicine·K SugiyamaY Wada

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