Homophilic interaction of the L1 family of cell adhesion molecules.

Experimental & Molecular Medicine
Chun Hua Wei, Seong Eon Ryu

Abstract

Homophilic interaction of the L1 family of cell adhesion molecules plays a pivotal role in regulating neurite outgrowth and neural cell networking in vivo. Functional defects in L1 family members are associated with neurological disorders such as X-linked mental retardation, multiple sclerosis, low-IQ syndrome, developmental delay, and schizophrenia. Various human tumors with poor prognosis also implicate the role of L1, a representative member of the L1 family of cell adhesion molecules, and ectopic expression of L1 in fibroblastic cells induces metastasis-associated gene expression. Previous studies on L1 homologs indicated that four N-terminal immunoglobulin-like domains form a horseshoe-like structure that mediates homophilic interactions. Various models including the zipper, domain-swap, and symmetry-related models are proposed to be involved in structural mechanism of homophilic interaction of the L1 family members. Recently, cryo-electron tomography of L1 and crystal structure studies of neurofascin, an L1 family protein, have been performed. This review focuses on recent discoveries of different models and describes the possible structural mechanisms of homophilic interactions of L1 family members. Understanding structu...Continue Reading

References

Nov 1, 1992·The Journal of Experimental Medicine·K KatoH Yagita
Jul 1, 1991·The Journal of Cell Biology·A AchesonU Rutishauser
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·A F WilliamsA N Barclay
Apr 1, 1995·Trends in Neurosciences·E V WongV Lemmon
Apr 1, 1996·The Journal of Cell Biology·R RamanathanM E Charness
Dec 1, 1998·Journal of Neurochemistry·M F Wilkemeyer, M E Charness
Oct 6, 1999·Current Opinion in Cell Biology·M S Steinberg, P M McNutt
Apr 20, 2002·Science·Titus J BoggonLawrence Shapiro
Feb 25, 2003·Annual Review of Neuroscience·Genevieve Rougon, Oliver Hobert
Apr 7, 2004·The Journal of Cell Biology·Kyoko ItohVance Lemmon
Oct 7, 2004·Current Opinion in Structural Biology·Iwona Bucior, Max M Burger
Dec 8, 2004·The European Journal of Neuroscience·Thomas PrussHansjürgen Volkmer
Jan 25, 2005·Neurochemical Research·Peter S WalmodElisabeth Bock
Oct 24, 2006·Nature Reviews. Molecular Cell Biology·Nicholas K Tonks
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karin KnoglerIlse Novak-Hofer
Jun 30, 2007·Annual Review of Neuroscience·Lawrence ShapiroDavid R Colman
Aug 28, 2007·Nature·Rob MeijersDietmar Schmucker
Sep 4, 2007·Protein Science : a Publication of the Protein Society·Mario MörtlWolfram Welte

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Citations

Aug 9, 2015·Molecular Neurobiology·Hardeep KatariaGabriele Loers
Jun 9, 2016·Progress in Histochemistry and Cytochemistry·Timur R SamatovAlexander G Tonevitsky
Aug 28, 2016·Biochimica Et Biophysica Acta. General Subjects·Dorota Hoja-ŁukowiczMonika Bubka
Oct 20, 2015·Trends in Pharmacological Sciences·Federico Colombo, Jacopo Meldolesi
Jul 14, 2016·The EMBO Journal·Matt C Danzi, Vance P Lemmon
Sep 29, 2020·Journal of Neurochemistry·Ralf KleeneMelitta Schachner
Jan 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriele LoersMelitta Schachner
Mar 2, 2021·Frontiers in Neural Circuits·Sahar PourhoseiniElizabeth Zuniga-Sanchez
Feb 26, 2019·Current Biology : CB·Kacy L GordonDavid R Sherwood

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Methods Mentioned

BETA
glycosylation
surface plasmon resonance
glycosylations
gel filtration

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