PMID: 8963898Mar 1, 1996Paper

Homoplasy for size at microsatellite loci in humans and chimpanzees

Genome Research
J C Garza, N B Freimer

Abstract

Homoplasy (convergence in the size of different alleles) at microsatellite loci was examined by sequencing multiple alleles of two compound microsatellites and single copies of alleles of the same size at two other compound loci in both chimpanzees and humans. At one of the two loci for which multiple alleles were sequenced, extensive homoplasy for size was uncovered both within and between species. At the three loci for which alleles of the same size were examined in the two species, sequencing demonstrated different internal structures. These results confirm theoretical predictions that a certain fraction of mutations at microsatellite loci should produce alleles that are identical in size but differ by a number of mutations. The sequence data reveal a previously unrecognized class of variation at microsatellites and open up the possibility that DNA sequencing may allow the extraction of more information from these loci, thus increasing their power as variable markers for genetic mapping studies. Conversely, the data also indicate that the assumption that alleles of the same size are identical in sequence, which is implicit in several methods of analysis, is violated in some cases. Therefore, caution should be used when emplo...Continue Reading

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Citations

Apr 29, 1998·Journal of Molecular Evolution·C C MuirA T Beckenbach
Feb 24, 2012·PLoS Genetics·Raquel Assis, Alexey S Kondrashov
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·L JinE Mignot
Oct 6, 1999·Genome Research·L N BullN B Freimer
Nov 2, 2002·Molecular Biology and Evolution·Scott M BlankenshipDennis Hedgecock
Jul 5, 2005·The Journal of Heredity·L D Shepherd, D M Lambert
May 25, 2001·Journal of Medical Entomology·C LunaL Zheng
Feb 26, 2016·Royal Society Open Science·Salla VartiaJens Carlsson
May 13, 2015·Molecular Ecology Resources·Hilary A StarksJohn Carlos Garza
Apr 27, 2002·American Journal of Primatology·L GusmãoA Carracedo
Apr 29, 2006·Ecology Letters·Kimberly A Selkoe, Robert J Toonen
Oct 8, 2015·Canadian Journal of Microbiology·Zarrin Basharat, Azra Yasmin
Jun 21, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Josephine F ReyesMark M Tanaka
Jun 19, 2007·Genomics, Proteomics & Bioinformatics·Hao Fan, Jia-You Chu
Jul 25, 2000·Insect Molecular Biology·M BonizzoniL Zheng
Mar 11, 2000·American Journal of Primatology·I ClissonB Crouau-Roy
Nov 17, 2017·Molecular Ecology Resources·Diana S BaetscherJohn C Garza
Dec 3, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·V K KishoreS J Knapp
Feb 21, 1998·Genome Research·H WenzJ W Efcavitch
Feb 10, 2000·Molecular Biology and Evolution·S M FullertonJ B Clegg

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