PMID: 6163302Jul 1, 1980Paper

Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with progressive myoclonus epilepsy

Acta Neurologica Scandinavica
E LeinoP J Riekkinen

Abstract

The possibility of disturbed dopamine and serotonin metabolism in the progressive myoclonus epilepsy (PME) occurring in Finland (a type of PME without Lafora bodies) was examined. Both basal concentrations of HVA and 5-HIAA in the CSF and their increase after oral probenecid administration were studied in 19 PME patients and in 19 age- and sex-matched control patients. The control patients had grand mal epilepsy but not myoclonus or ataxia. The basal value of HVA was significantly reduced and that of 5-HIAA was also slightly reduced in the PME patients as compared to the values of the epileptic controls or to those of 26 nonepileptic controls. The concentrations of HVA and 5-HIAA also seemed to correlate with the severity of the PME. The most severely affected patients had generally the lowest values. After oral probenecid this trend was also seen when the increases of HVA and 5-HIAA were expressed per microgram CSF probenecid, i.e. the mildly affected PME group showed higher increases in response to probenecid than the most severely affected PME group. The PME patients had higher probenecid levels in the CSF than the epileptic controls.

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Citations

Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D LouwJ Girvin
Sep 1, 1983·Neurochemical Research·M Hiramatsu
Apr 1, 1983·Epilepsia·R Riikonen
Jan 1, 1993·Epilepsia·S F BerkovicF Andermann
Dec 6, 2001·Current Treatment Options in Neurology·Basim M. Uthman, Andreas Reichl
Sep 1, 1986·The Japanese Journal of Psychiatry and Neurology·M HiramatsuA Mori
Oct 1, 1982·Neurochemical Research·M HiramatsuA Mori
Dec 1, 1983·Acta Neurologica Scandinavica·L BaligaS N Rao
May 9, 2007·Epilepsia·Miikka KorjaReijo J Marttila

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