PMID: 6172950Aug 1, 1981Paper

Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type

Acta Neurologica Scandinavica
H SoininenP J Riekkinen

Abstract

The possibility of disturbed dopamine and serotonin metabolism in senile dementia of Alzheimer type was studied. The basal concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) were studied in 28 patients with senile dementia of Alzheimer type and in 13 controls of similar age with no neurological disease. The concentrations of HVA were significantly reduced in the dementia patients compared to the concentrations of the controls. The values of HVA were also significantly reduced in the most severely demented patients compared to the less severely demented ones. There was a slight but statistically significant decrease in the 5-HIAA levels in the dementia patients compared to the levels of the controls. The 5-HIAA levels were reduced in the most severely demented patients compared to the controls but not when compared with the less severely demented patients. It is concluded that in severe forms of senile dementia of Alzheimer type, there is a decrease in the levels of HVA and 5-HIAA in CSF which may reflect a decreased turnover of dopamine and serotonin. Patients diagnosed as senile dementia of Alzheimer type, but with less severe symptoms, had levels of HVA and 5-HIAA si...Continue Reading

References

Apr 5, 1975·Lancet·D A Drachman, S Stahl
Oct 20, 1979·Lancet·C M YatesA Gordon
Sep 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·R AdolfssonB Winblad
Jan 1, 1977·Acta Psychiatrica Scandinavica·V KristensenA Theilgaard
Mar 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·C G GottfriesG Sundbärg
May 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·C G GottfriesB E Roos
Jun 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·D M MannS Toper

❮ Previous
Next ❯

Citations

Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·H J KoponenE Leinonen
Jan 1, 1993·Journal of Neural Transmission. General Section·A M Palmer, S T DeKosky
Jun 1, 1990·Journal of the American Geriatrics Society·R T Bartus
Sep 1, 1990·Journal of the American Geriatrics Society·D MungasC Bernick
Jan 1, 1985·Annals of the New York Academy of Sciences·R T BartusC Flicker
May 1, 1985·Acta Neurologica Scandinavica·P SeeldrayersJ Hildebrand
Jul 1, 1989·Acta Neurologica Scandinavica·M DuretJ Hildebrand
Jan 1, 1991·Journal of Neural Transmission. General Section·P HartikainenP J Riekkinen
Feb 1, 1988·Acta Psychiatrica Scandinavica·I KarlssonE Rybo
Jan 1, 1992·Journal of Neural Transmission. General Section·N PomaraD Deptula
Nov 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H TeräväinenD B Calne
Jul 1, 1996·The International Journal of Neuroscience·R Sandyk
Oct 1, 1991·Journal of the American Geriatrics Society·W A van Gool, P A Bolhuis
Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E MartignoniG Nappi
May 1, 1992·Acta Neurologica Scandinavica·J HildebrandS Przedborski
Oct 1, 1985·Journal of the American Geriatrics Society·O J ThienhausH B Bosmann
Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H SoininenP J Riekkinen
Feb 1, 1992·Molecular and Chemical Neuropathology·L ParnettiU Senin
Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·P HartikainenP J Riekkinen
Jan 1, 1985·Annals of the New York Academy of Sciences·B WinbladL G Nilsson
Feb 1, 1995·Journal of the American Geriatrics Society·K RohdeM A Raskind
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·G L CoronaF Savoldi
May 1, 1990·Acta Neurologica Scandinavica·J HildebrandS Goldman
Jun 29, 2021·Experimental Gerontology·Alessandra GalloRomain Verpillot
Jan 1, 1988·Movement Disorders : Official Journal of the Movement Disorder Society·R MayeuxL J Cote

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.