PMID: 2487143Sep 1, 1989Paper

Homozygosity for 8pter----q22 in acute myeloblastic leukemia with t(8;21)(q22;q22)

Genes, Chromosomes & Cancer
R Berger

Abstract

A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter----8q22 is reported. A t(8;21)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q- and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q22----qter. This case shows that acquired hemizygosity and homozygosity do exist in leukemia as in solid malignant tumors.

References

Jan 1, 1979·Cytogenetics and Cell Genetics·U FranckeV M Riccardi
Jan 1, 1978·American Journal of Diseases of Children·J J Yunis
Jun 1, 1977·Clinical Genetics·R BergerC Schenmetzler
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M F HansenW K Cavenee
Aug 1, 1988·British Journal of Cancer·A R Green
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M O DiazJ D Rowley
Nov 1, 1987·Cancer Genetics and Cytogenetics·R BergerF Sigaux
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S H FriendR A Weinberg
Mar 9, 1984·Science·A L Murphree, W F Benedict

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Citations

Mar 1, 1991·Cancer Genetics and Cytogenetics·A Butturini, R P Gale
Oct 15, 1993·Cancer Genetics and Cytogenetics·R BergerA Bussel
Aug 8, 2006·American Journal of Clinical Pathology·Jose R ValbuenaPei Lin
Oct 17, 2002·Annales de génétique·Roland Berger, Maryvonne Busson

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