PMID: 7542912Jun 1, 1995Paper

Homozygous deletions and loss of expression of the CDKN2 gene occur frequently in head and neck squamous cell carcinoma cell lines but infrequently in primary tumors

Genes, Chromosomes & Cancer
W M LydiattR S Chaganti

Abstract

Deletion of 9p21-22 is a common genetic alteration in dysplastic, in situ, and invasive head and neck squamous cell carcinoma (HNSCC). However, a candidate tumor suppressor gene (TSG) at this site has thus far not been identified in HNSCC. We report homozygous deletion of the recently identified multiple tumor suppressor I (MTSI)/cyclin-dependent kinase-4-inhibitor (CDKN2) gene mapped to 9p21, which encodes the p16 protein, a regulator of cyclin-dependent kinase 4, in six of 16 HNSCC cell lines. We also show absence of the CDKN2 mRNA in all cell lines with CDKN2 deletion as well as in an additional two cell lines without deletion. Overall, we have identified 9p abnormalities in 12 of 16 (75%) cell lines, at least nine of which involved CDKN2. We further demonstrate that the CDKN2 deletion in HNSCC is located within a previously described region of allelic loss between D9S171 and IFNW, which spans a 4 cM region of 9p. However, examination of 36 primary tumors revealed genetic alterations in only seven of 36 (19%) tumors. These results suggest that genetic alterations at CDKN2 are frequent in HNSCC cell lines, but the role of this gene in primary tumors is less compelling. CDKN2 does not appear to be the only TSG on 9p21 in HNSCC...Continue Reading

References

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Citations

May 18, 1999·International Journal of Cancer. Journal International Du Cancer·P JaresE Campo
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·S I BaeW H Kim
Jan 22, 2002·Cancer Genetics and Cytogenetics·Micaela PoetschBritta Kleist
Jan 1, 1997·Cancer Genetics and Cytogenetics·Y RemvikosB Dutrillaux
Oct 1, 1996·Leukemia & Lymphoma·M Heyman, S Einhorn
Jul 1, 1996·Leukemia & Lymphoma·V BrunelF Birg
Dec 23, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Shinsuke OhtaYoshinobu Kubota
Dec 24, 2013·International Journal of Genomics·Glenn JenkinsDerek J Richard
Nov 26, 1999·British Journal of Cancer·E C MiraccaM A Nagai
Oct 21, 2005·World Journal of Gastroenterology : WJG·Po ZhaoYa-Li Lu
Jun 29, 2012·Oncology Letters·Kiyoto ShigaToshimitsu Kobayashi
Mar 4, 1998·Head & Neck·W M LydiattR S Chaganti
Nov 21, 1998·Biochimica Et Biophysica Acta·M Ruas, G Peters

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