Homozygous deletions on the short arm of chromosome 3 in human oral squamous cell carcinomas

Oral Oncology
N UzawaM A Yoshida

Abstract

Recent cytogenetic and allelic deletion analyses have demonstrated that deletions on the short arm of chromosome 3 (3p) are frequently found in various cancers, including oral squamous cell carcinomas (OSCCs). This suggests that one or more tumor suppressor gene(s) for these malignancies might be located on 3p. In the present study, to further define the region(s) on 3p that harbor putative tumor suppressor gene(s) for OSCCs, we have investigated the existence of homozygous deletions (HDs) at 34 loci on 3p, in 14 OSCC cell lines. HDs were detected within the FRA3B region at 3p14.2 in only two cell lines (HSC-4 and TSU). Recently, the human fragile histidine triad (FHIT) gene was isolated from this region, abnormalities of which have been found at high frequencies in several types of human cancers. We also examined the expression of the FHIT gene, using reverse transcription-polymerase chain reaction (RT-PCR) and exon-specific PCR, in the two OSCC cell lines which showed HDs at 3p14.2. There was no detectable expression of exon 5, which was the first protein-coding exon of FHIT gene, in HSC-4 cells, indicating that this region was homozygously deleted in this cell line. On the other hand, HD in the TSU cells did not affect the c...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·E SakaiN Tsuchida
Dec 1, 1990·Archives of Otolaryngology--head & Neck Surgery·W D MerrittT M Gilmer
Mar 1, 1984·The New England Journal of Medicine·T P DryjaG A Bruns
Mar 1, 1994·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S HosoeT Kishimoto
Sep 15, 1994·International Journal of Cancer. Journal International Du Cancer·K UzawaK Sato
May 15, 1994·International Journal of Cancer. Journal International Du Cancer·D L BuchhagenP Etkind
May 1, 1993·Current Opinion in Oncology
Jun 17, 1993·The New England Journal of Medicine·A Mashberg
Apr 5, 1996·Cell·G SozziC M Croce
Jan 1, 1996·Cytogenetics and Cell Genetics·A van den BergC H Buys
Feb 1, 1997·Human Molecular Genetics·F BoldogH A Drabkin
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z SiprashviliK Huebner
Apr 1, 1998·Journal of the National Cancer Institute·L Mao

❮ Previous
Next ❯

Citations

Dec 20, 2013·Cellular Oncology (Dordrecht)·Ilda Patrícia RibeiroIsabel Marques Carreira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.