Homozygous p53 gene mutation in a radiation-induced glioblastoma 10 years after treatment for an intracranial germ cell tumor: case report

Neurosurgery
M TadaR Iggo

Abstract

Radiation-induced glioma is a rare but serious complication of radiotherapy. Underlying radiation-induced mutations in oncogenes or tumor suppressor genes have not previously been described. A 16-year-old female patient developed a glioblastoma in the right frontal lobe 10 years after treatment of a suprasellar germ cell tumor with 50 Gy ionizing radiation. The glioblastoma was undetectable on a high-resolution magnetic resonance image obtained 3 months before diagnosis. A p53 functional assay was used to examine the transcriptional competence of the p53 tumor suppressor gene. This assay scores the content of mutant p53 alleles in tumor and blood samples quantitatively as a percentage of red yeast colonies. The glioblastoma contained 95% mutant p53 alleles, whereas blood from the patient and her parents contained only normal background levels of red colonies. Sequencing revealed that the mutation in the tumor was a 3-base pair deletion affecting codons 238 and 239. Intragenic deletion within the p53 deoxyribonucleic acid binding domain is uncommon in sporadic tumors but would be entirely consistent with misrepair of a radiation-induced double-strand deoxyribonucleic acid break in this case. This is the first case in which a cau...Continue Reading

References

Jan 1, 1990·Neuroradiology·C BazanK S Kagan-Hallet
Sep 1, 1987·Annals of Neurology·E J DropchoJ C Allen
Dec 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·C I HuangD M Ho
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J WongB Vogelstein
Jan 1, 1972·Acta Neuropathologica·W HaymakerJ Miquel
Jan 1, 1980·AJR. American Journal of Roentgenology·M Brant-ZawadzkiR W Jahnke
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M FlamanJ Benhattar
Dec 22, 1994·Nature·A ZieglerD E Brash
Dec 1, 1994·Molecular Carcinogenesis·A OotsuyamaH Tanooka
May 1, 1993·International Journal of Radiation Biology·D T GoodheadR Cox
Jan 1, 1993·Brain Pathology·A von DeimlingD N Louis
Jan 1, 1994·Journal of Neuropathology and Experimental Neurology·D N Louis
Jul 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V P Collins, C D James

❮ Previous
Next ❯

Citations

Apr 9, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Benedetta Ludovica PettoriniConcezio Di Rocco
Jun 21, 2008·Journal of Neuro-oncology·Maurizio SalvatiRoberto Delfini
May 3, 2011·Journal of Neuro-oncology·Hideo NakamuraJun-ichi Kuratsu
Sep 17, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Elida VázquezJavier Lucaya
Feb 24, 2006·Carcinogenesis·Nathalie Gonin-LaurentBernard Malfoy
Dec 27, 2005·Expert Review of Anticancer Therapy·Tatsuya OhnoYoshiya Shimada
Jul 7, 2009·Journal of Neurosurgery·Matthew L CarlsonMichael J Link
Oct 7, 2016·Neurosurgical Review·Ryuya YamanakaTomohiko Kanayama
Apr 1, 2008·Journal of Neuro-oncology·Takashi SasayamaEiji Kohmura
Oct 6, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Bernd F M RomeikeNorbert Graf
Apr 5, 2011·Journal of Neurosurgery. Pediatrics·Hideo NakamuraJun-ichi Kuratsu
Feb 28, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Akari MakidonoKoyu Suzuki
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·T JoachimA von Deimling
May 18, 1999·The American Journal of Pathology·D J BratP C Burger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
T Ichikawa
Cancer Treatment and Research
E Liu, B Weissman
Transactions & Studies of the College of Physicians of Philadelphia
R A Weinberg
Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
M Ponz de Leon
© 2022 Meta ULC. All rights reserved