Honeycomb-structured metasurfaces for the adaptive nesting of endothelial cells under hemodynamic loads

Biomaterials Science
Bjoern Johann BachmannAldo Ferrari

Abstract

The thrombogenicity of artificial materials comprising ventricular assist devices (VADs) limits their long-term integration in the human body. A living endothelium covering the luminal surface can provide a safe interface working compatibly with blood and circumventing this problem. However, the survival of endothelial cells is endangered by non-physiological hemodynamic conditions generated by VAD function, including high wall shear stress and deformation. Here, we introduce a surface topography comprising hexagonal honeycomb shelters in which cells remodel to generate coherently organized patterns of subcellular compartments. The resulting hexagonal array shows resistance to supraphysiological loads maintaining endothelium integrity and avoiding local discontinuities.

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Citations

Sep 10, 2020·Annals of Biomedical Engineering·Aldo FerrariEdoardo Mazza
Sep 11, 2020·Nature Reviews. Cardiology·Emanuela S FiorettaMaximilian Y Emmert
Dec 6, 2020·Photochemistry and Photobiology·Alejandra Magaly Reyes LuaAldo Ferrari
Mar 9, 2021·BioMed Research International·Veera Venkata Satya Varaprasad Jakka, Jiri Bursa
Jun 4, 2021·Nano Letters·Nafsika ChalaAldo Ferrari

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Methods Mentioned

BETA
nuclear translocation
Scanning Electron Microscopy

Software Mentioned

MUMPS
Fiji
COMSOL Multiphysics
Siemens NX
EULER
COMSOL

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