Honey/PVA hybrid wound dressings with controlled release of antibiotics: Structural, physico-mechanical and in-vitro biomedical studies

Materials Science & Engineering. C, Materials for Biological Applications
Javad Tavakoli, Youhong Tang

Abstract

Hydrogel/honey hybrids manifest an attractive design with an exclusive therapeutic property that promotes wound healing process. The greater the concentration of honey within the formulation, the better the biomedical properties that will be achieved. However, an increase in the percentage of honey can negatively affect the physico-chemical and mechanical properties of hybrid hydrogels. The need exists, therefore, to prepare wound dressings that contain high honey density with optimal biomedical, mechanical and physicochemical properties. In this study, a simple method for the preparation of a highly concentrated honey/PVA hybrid hydrogel with borax as the crosslinking agent is reported. Comprehensive evaluations of the morphology, swelling kinetics, permeability, bio-adhesion, mechanical characteristics, cytotoxicity, antibacterial property, cell proliferation ability and their controlling release properties were conducted as a function of crosslinking density. All the borax-induced hydrogels showed acceptable biocompatibility, and the incorporation of 1% borax in the hydrogel formulation produced optimal behaviours for wound addressing applications.

Citations

Sep 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mihaela Violeta GhicaDenisa Ioana Udeanu
Sep 22, 2017·Current Medicinal Chemistry·Antonio FranceskoTzanko Tzanov
Oct 25, 2017·Marine Drugs·Luisa Fernanda Gómez ChabalaMartha Elena Londoño López
Sep 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irina NegutAlexandru Mihai Grumezescu
Aug 16, 2017·Polymers·Javad Tavakoli, Youhong Tang
Nov 19, 2019·Advances in Wound Care·Katherine R HixonScott A Sell
Apr 2, 2019·Pharmaceutical Development and Technology·Jingjunjiao LongAli Seyfoddin
Aug 17, 2019·Current Medicinal Chemistry·Javad TavakoliYouhong Tang
Feb 6, 2021·Topics in Current Chemistry·Javad TavakoliYouhong Tang
Dec 3, 2020·Clinical, Cosmetic and Investigational Dermatology·Pauline McLooneLorna Fyfe
Jan 21, 2021·Biomimetics·Martina Rossi, Pasquale Marrazzo
Jan 30, 2021·International Journal of Biological Macromolecules·Ling DingJi Zhang
Mar 5, 2021·Journal of Pharmaceutical Sciences·Íngara Keisle São Paulo Barretto MirandaSandra Aparecida de Assis
Sep 23, 2019·Biosensors & Bioelectronics·Stuart HannahDamion K Corrigan
Apr 26, 2021·International Journal of Biological Macromolecules·Chuanjie LiuJianxin Jiang
Jun 15, 2021·Journal of Wound Care·Fahimeh Farshi AzharMehran Mesgari-Abbasi
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Željka Peršurić, Sandra Kraljević Pavelić
Aug 9, 2021·Carbohydrate Polymers·Mohamed Ahmed Mohamady HusseinMosaad Megahed
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hana ScepankovaLetícia M Estevinho
Aug 29, 2021·Advanced Healthcare Materials·Huan LeiDaidi Fan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of Pharmacy and Pharmacology
J T SCALES
Ugeskrift for laeger
J P Schougaard
Medizinische Monatsschrift für Pharmazeuten
Arne Simon
© 2022 Meta ULC. All rights reserved