Honokiol downregulates Kruppel-like factor 4 expression, attenuates inflammation, and reduces histopathology after spinal cord injury in rats

Spine
Jia LiuTiansheng Sun

Abstract

Randomized experimental study. To investigate the neuroprotective effect of honokiol (HNK) on rats subjected to traumatic spinal cord injury (SCI) and the molecular mechanisms. Inflammation contributes to the secondary injury to the spinal cord. Honokiol has been used as a neuroprotective agent because of its strong antioxidant and anti-inflammatory properties. Kruppel-like factor 4 (Klf4) is a newly identified critical target for the anti-inflammatory effect of HNK. Whether HNK can inhibit inflammatory response in rat model of SCI through mediating the expression of Klf4 has yet to be elucidated. Eighty-four adult female Sprague-Dawley rats were randomly divided into 4 groups as sham, SCI, SCI + Vehicle (0.1% propylene glycol in saline, intraperitoneally), and SCI + HNK (20 mg/kg, intraperitoneally) groups. The influences of HNK on the proinflammatory cytokines, microglial activation, neutrophil infiltration, histological changes, and improvement in motor function were assessed. In the SCI group, proinflammatory cytokines, microglial activation, neutrophil infiltration, and Klf4 expression levels were increased compared with the sham group (P < 0.001). HNK intervention downregulated the expression of Klf4, reduced the producti...Continue Reading

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Citations

Jul 2, 2016·The Journal of Surgical Research·Jiang WuZhu Liulong
Jun 9, 2016·Molecular Nutrition & Food Research·Jing PanMing You
Oct 27, 2017·Journal of Neuroinflammation·Wu JiangLiulong Zhu
Apr 23, 2016·Journal of Neurosurgery. Spine·John T StreetCharles G Fisher
May 20, 2017·Experimental & Molecular Medicine·Harlan BarkerTero Ah Järvinen
Aug 30, 2019·IBRO Reports·Sumit BaruaJong Eun Lee
Jan 16, 2021·Cells·Ganchimeg DavaaJung Keun Hyun
Jul 30, 2021·Journal of Orthopaedic Surgery·Yiguang Zhou, Feng Yu
Aug 8, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Abdur RaufMohammad Ali Shariati

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