Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis

Life Sciences
Lan ChenDaoxin Wang

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inflammation and oxidative stress. However, whether HKL has protective effects against the dysfunction of pulmonary microvascular endothelial barrier and the potential mechanisms remain unclear. In the present study, we examined the levels of plasma Angiopoietin-2 (Ang-2) in ARDS patients, explored the effects of HKL on the vascular endothelial barrier at the ARDS animal and cell levels. Our data showed that compared with the healthy controls, circulating Ang-2 level was higher in the patients with ARDS, and were usually supposed to be positively related to the severity of ARDS. Moreover, HKL effectively inhibited lung inflammatory injury and microvascular leakage, and improved ARDS mice survival. HKL also inhibited the expression of Ang-2, ICAM-1 and VCAM-1, and restored the expression of Sirt3, β-Catenin and VE-Cadherin. Furthermore, HKL improved ECs survival and inhibited the apoptosis of ECs. The inhibition of Ang-2 e...Continue Reading

Citations

Mar 17, 2020·Expert Opinion on Therapeutic Targets·Vidula Vachharajani, Charles E McCall
Oct 18, 2019·Frontiers in Pharmacology·Shiyun PuJinhan He
Nov 26, 2020·International Journal of Molecular Sciences·Alice G VassiliouStylianos E Orfanos
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Dec 29, 2020·Alcoholism, Clinical and Experimental Research·Anugraha GandhirajanVidula Vachharajani
Mar 6, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiyang YangJianghong Yan
Dec 3, 2020·Research in Veterinary Science·Yaser Jafari-KhataylouNavideh Mirzakhani

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