Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial.

JAMA Neurology
Radu TanasescuD I Pritchard

Abstract

Studies suggest gut worms induce immune responses that can protect against multiple sclerosis (MS). To our knowledge, there are no controlled treatment trials with helminth in MS. To determine whether hookworm treatment has effects on magnetic resonance imaging (MRI) activity and T regulatory cells in relapsing MS. This 9-month double-blind, randomized, placebo-controlled trial was conducted between September 2012 and March 2016 in a modified intention-to-treat population (the data were analyzed June 2018) at the University of Nottingham, Queen's Medical Centre, a single tertiary referral center. Patients aged 18 to 61 years with relapsing MS without disease-modifying treatment were recruited from the MS clinic. Seventy-three patients were screened; of these, 71 were recruited (2 ineligible/declined). Patients were randomized (1:1) to receive either 25 Necator americanus larvae transcutaneously or placebo. The MRI scans were performed monthly during months 3 to 9 and 3 months posttreatment. The primary end point was the cumulative number of new/enlarging T2/new enhancing T1 lesions at month 9. The secondary end point was the percentage of cluster of differentiation (CD) 4+CD25highCD127negT regulatory cells in peripheral blood. ...Continue Reading

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Citations

Jan 25, 2021·QJM : Monthly Journal of the Association of Physicians·L DumitrescuR Tanasescu
Jan 30, 2021·Clinical and Translational Gastroenterology·John CroesePaul R Giacomin
Apr 4, 2021·International Journal of Molecular Sciences·Sameeksha ChopraAntoine Dufour
Mar 2, 2021·Annual Review of Immunology·Bonnie DouglasDe'Broski R Herbert
May 11, 2021·Autoimmunity Reviews·Giuseppe MurdacaSebastiano Gangemi
Jun 25, 2021·Seminars in Immunopathology·E Mitre, A D Klion
Jul 19, 2021·Autoimmunity Reviews·Amirhossein Azari JafariReza Jafari
Aug 11, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Calogero Edoardo CiceroAlessandra Nicoletti
Sep 9, 2021·Expert Review of Neurotherapeutics·Amin ZarghamiBruce V Taylor
Dec 10, 2021·PLoS Neglected Tropical Diseases·Paul R ChapmanJames S McCarthy
Feb 4, 2022·PLoS Pathogens·Ali Hassan, Nicolas Blanchard

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