Horizontal cell gap junctions: single-channel conductance and modulation by dopamine.

Proceedings of the National Academy of Sciences of the United States of America
D G McMahonJ E Dowling

Abstract

Horizontal cells form an electrically coupled network for the transmission of inhibitory signals in the outer retina. In teleosts, horizontal cell coupling is modulated by the neurotransmitter dopamine. Using voltage-clamped pairs of teleost horizontal cells, we have examined the effects of dopamine on the conductance and gating properties of the cell-to-cell channels that mediate electrical synaptic transmission. Variance analysis of the junctional current noise showed that dopamine substantially reduced the open probability of gap junction channels, from 0.75 to 0.14. Direct observation of unitary junctional gating events in poorly coupled cell pairs indicated that these channels have a unitary conductance of 50-60 pS. The elementary conductance of channels in cell pairs treated with dopamine (48.7 +/- 6.6 pS) was statistically indistinguishable from channels in untreated cells (53.2 +/- 7.2 pS). Uncoupling with octanol also yielded a similar unitary conductance (61.1 +/- 11.1 pS). Our results suggest that dopamine reduces the open probability of gap junctional channels by decreasing their open duration.

References

Jan 1, 1979·Journal of Neuroscience Research·K Negishi, B D Drujan
Sep 2, 1985·Nature·J Neyton, A Trautmann
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D C SprayE L Hertzberg
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J M Burt, D C Spray
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E M Lasater
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C SaezM V Bennett
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E M Lasater, J E Dowling
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R Van Buskirk, J E Dowling
Jan 1, 1984·Biophysical Journal·D C SprayM V Bennett

❮ Previous
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Citations

Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H J DonahueP R Brink
Jun 30, 2000·Cell Biology International·D BeckerP Mobbs
Jan 25, 2012·Invertebrate Neuroscience : in·Alexander V Sidorov
Jan 1, 1991·Progress in Biophysics and Molecular Biology·R L Winslow, A G Knapp
Oct 1, 1992·Brain Research. Molecular Brain Research·A L HarrisJ Zimmerberg
Feb 1, 1992·Neurochemistry International·M B Djamgoz, H J Wagner
Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T L DyakonovaW Winlow
Jan 1, 1992·Electron Microscopy Reviews·B Leitch
Apr 13, 1999·Trends in Neurosciences·J Cudeiro, C Rivadulla
Jul 1, 1991·Visual Neuroscience·J E Dowling
Aug 23, 2007·Visual Neuroscience·Stephen L MillsDavid W Marshak
Aug 1, 1994·Zygote : the Biology of Gametes and Early Embryos·R L DeHaan
Jun 6, 2009·Nature Reviews. Neuroscience·Stewart A Bloomfield, Béla Völgyi
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A G KnappJ E Dowling
Feb 1, 1996·Molecular Biology of the Cell·J O'BrienH Ripps
May 15, 1996·European Journal of Biochemistry·R BruzzoneD L Paul
Jun 26, 2004·Annual Review of Neuroscience·Barry W Connors, Michael A Long
May 20, 2011·Journal of Neurophysiology·Colin G EvansElizabeth C Cropper
Jan 30, 2009·Journal of Neurophysiology·Ziyi SunDouglas G McMahon
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·D Q Zhang, D G McMahon
Aug 15, 2012·The Journal of Physiology·Duco EndemanMaarten Kamermans
Jul 11, 2012·Brain Research·Espen Hartveit, Margaret Lin Veruki
Feb 5, 2008·Journal of Chemical Neuroanatomy·Xesús M AbaloM Celina Rodicio
Jul 6, 2006·The European Journal of Neuroscience·Jennifer ShelleyReto Weiler
Aug 16, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Bettina C SchwabRichard J A van Wezel
Jan 1, 1994·Progress in Biophysics and Molecular Biology·W C De Mello
Jun 5, 2012·Biochimica Et Biophysica Acta·Alberto E PeredaJohn E Rash
Jan 15, 2013·Progress in Retinal and Eye Research·Béla VölgyiRóbert Gábriel
Dec 1, 1996·Vision Research·N Vardi, R G Smith

❮ Previous
Next ❯

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