Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen

Proceedings of the National Academy of Sciences of the United States of America
Braham DhillonRichard C Hamelin

Abstract

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems.

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Citations

Jun 12, 2016·Genome Biology and Evolution·Alison C TestaJames K Hane
Jun 14, 2016·Molecular Plant Pathology·Elisha ThynnePeter S Solomon
Feb 22, 2018·The ISME Journal·Emile Gluck-Thaler, Jason C Slot
Mar 2, 2018·PeerJ·Nicolas FeauRichard C Hamelin
Feb 13, 2020·Tree Physiology·Baoguang Liu, Jack P Wang
May 19, 2020·Molecular Biology and Evolution·Emile Gluck-ThalerJason C Slot
Jan 4, 2020·Natural Product Reports·Antonis RokasNicholas H Oberlies
Sep 6, 2020·Molecular Plant Pathology·Aline Lacaze, David L Joly
Jan 2, 2020·Evolutionary Applications·Richard C Hamelin, Amanda D Roe
Nov 18, 2020·Phytopathology·Pauline HessenauerRichard C Hamelin

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