Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae.

Science Advances
Sonja LehtinenRafal J Mostowy

Abstract

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move between genetic lineages is an open question, which we address in the context of antibiotic resistance in Streptococcus pneumoniae. We analyze microbiological, genomic, and epidemiological data from the largest-to-date sequenced pneumococcal carriage study in 955 infants from a refugee camp on the Thailand-Myanmar border. Using a unified framework, we simultaneously test prior hypotheses on rates of HGT and a key evolutionary covariate (duration of carriage) as determinants of resistance frequencies. We conclude that in this setting, there is little evidence of HGT playing a major role in determining resistance frequencies. Instead, observed resistance frequencies are best explained as the outcome of selection acting on a pool of variants, irrespective of the rate at which resistance determinants move between genetic lineages.

References

Sep 2, 2008·Studies in History and Philosophy of Biological and Biomedical Sciences·Maureen A O'Malley
Oct 4, 2008·Nucleic Acids Research·Bo Liu, Mihai Pop
Jun 13, 2009·Science·William Paul HanageJukka Corander
Jun 13, 2009·PLoS Pathogens·Daniel M WeinbergerMarc Lipsitch
Mar 10, 2010·BMC Bioinformatics·Doug HyattLoren J Hauser
Sep 30, 2010·Bioinformatics·Ofir CohenTal Pupko
Jan 29, 2011·Science·Nicholas J CroucherStephen D Bentley
May 7, 2013·Nature Genetics·Nicholas J CroucherMarc Lipsitch
Feb 11, 2014·Nature Genetics·Claire ChewapreechaStephen D Bentley
Jun 12, 2014·Genome Biology and Evolution·Nicholas J CroucherStephen D Bentley
Nov 22, 2014·Nucleic Acids Research·Nicholas J CroucherSimon R Harris
Feb 6, 2015·Microbiology and Molecular Biology Reviews : MMBR·Hsiao-Han ChangMarc Lipsitch
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sonja LehtinenChristophe Fraser
Feb 16, 2017·Molecular Biology and Evolution·Rafal MostowyPekka Marttinen
Oct 17, 2017·Nature Biotechnology·Martin Steinegger, Johannes Söding
Oct 19, 2017·Nature Ecology & Evolution·Jukka CoranderNicholas J Croucher
Jul 28, 2018·Trends in Microbiology·Alvaro San Millan
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christine TedijantoMarc Lipsitch
Apr 21, 2019·EBioMedicine·Rebecca A GladstoneUNKNOWN Global Pneumococcal Sequencing Consortium
May 15, 2019·PLoS Pathogens·Sonja LehtinenUNKNOWN with the Maela Pneumococcal Collaboration
Sep 14, 2019·Science·R Craig MacLean, Alvaro San Millan

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Citations

Nov 6, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin J MetcalfBernard Beall
Jun 18, 2021·Evolution Letters·Sonja LehtinenSebastian Bonhoeffer
Sep 10, 2021·PLoS Pathogens·Matthew J Culyba, Daria Van Tyne

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Software Mentioned

GLOOME
Prodigal
Gubbins
mmseqs
ppcor R package

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