Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria.

PloS One
Thomas BrodyWard F Odenwald

Abstract

Acquisition of virulence factors and antibiotic resistance by many clinically important bacteria can be traced to horizontal gene transfer (HGT) between related or evolutionarily distant microflora. Comparative genomic analysis has become an important tool for identifying HGT DNA in emerging pathogens. We have adapted the multi-genome alignment tool EvoPrinter to facilitate discovery of HGT DNA sequences within bacterial genomes and within their mobile genetic elements. EvoPrinter analysis of 13 different Staphylococcus aureus genomes revealed that one of the human isolates, the hospital epidemic methicillin-resistant MRSA252 strain, uniquely shares multiple putative HGT DNA sequences with different causative agents of bovine mastitis that are not found in the other human S. aureus isolates. MRSA252 shares over 14 different DNA sequence blocks with the bovine mastitis ET3 S. aureus strain RF122, and many of the HGT DNAs encode virulence factors. EvoPrinter analysis of the MRSA252 chromosome also uncovered virulence-factor encoding HGT events with the genome of Listeria monocytogenes and a Staphylococcus saprophyticus associated plasmid. Both bacteria are also causal agents of contagious bovine mastitis. EvoPrinter analysis reve...Continue Reading

References

Jun 1, 1990·Molecular Microbiology·S J Rowland, K G Dyke
Apr 1, 1968·Journal of Bacteriology·R P Novick, C Roth
Nov 1, 1982·Antimicrobial Agents and Chemotherapy·F D PorterH Nakahara
Dec 29, 1980·FEBS Letters·D F Brown, P E Reynolds
Aug 1, 1994·FEMS Microbiology Reviews·D A Cooksey
Jun 1, 2000·Nature·H OchmanE A Groisman
Apr 17, 2001·Trends in Microbiology·E F BoydB Hochhut
Apr 5, 2002·Genome Research·W James Kent
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark C EnrightBrian G Spratt
Jun 5, 2002·Lancet·Tadashi BabaKeiichi Hiramatsu
Oct 31, 2002·Epidemiology and Infection·R N ZadoksY H Schukken
Oct 31, 2002·Molecular Microbiology·B Joseph HinnebuschElisabeth Carniel
Aug 26, 2003·Antimicrobial Agents and Chemotherapy·C MoubareckF Doucet-Populaire
Oct 30, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa SaimanPhyllis Della-Latta
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matthew T G HoldenJulian Parkhill
Apr 5, 2005·Journal of Bacteriology·Austin L Hughes, Robert Friedman
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ward F OdenwaldThomas Brody
Jan 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R Monina KlevensUNKNOWN National Nosocomial Infections Surveillance System
Feb 3, 2006·Functional & Integrative Genomics·Jodi A Lindsay, Matthew T G Holden
Feb 24, 2006·Infection and Immunity·Séverine Loisel-MeyerVéronique Jubier-Maurin
Aug 31, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Bryndis SigurdardottirLoreen A Herwaldt
Mar 30, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R H DeurenbergE E Stobberingh
Jun 8, 2007·Emerging Infectious Diseases·Eva Juhász-KaszanyitzkyJaap A Wagenaar
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Hidemasa NakaminamiMasanori Sasatsu
Oct 9, 2007·Current Opinion in Microbiology·Herminia de LencastreAlexander Tomasz
Oct 19, 2007·Nature·Mark J Pallen, Brendan W Wren
Nov 1, 2007·PloS One·Lisa Herron-OlsonVivek Kapur
Dec 8, 2007·American Journal of Infection Control·William R JarvisMarguerite Jackson
Mar 1, 2008·BMC Genomics·Amarendra S YavatkarWard F Odenwald
Mar 20, 2008·Journal of Dairy Science·R G M Olde RiekerinkD T Scholl

❮ Previous
Next ❯

Citations

May 31, 2011·Journal of Bacteriology·Cheong Xin ChanMark A Ragan
Jun 6, 2012·The Veterinary Clinics of North America. Food Animal Practice·Stephen P Oliver, Shelton E Murinda
Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Leah A Cohn, John R Middleton
Jan 13, 2011·FEMS Microbiology Reviews·Elizabeth Skippington, Mark A Ragan
Jun 30, 2009·Environmental Pollution·Jose Luis Martinez
Jan 27, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Amira KlibiAbderrazek Maaroufi
Mar 7, 2020·Frontiers in Microbiology·Chad M CullenGail L Rosen
Nov 17, 2020·PeerJ·Patrick F HorveKevin G Van Den Wymelenberg

❮ Previous
Next ❯

Datasets Mentioned

BETA
SAB0723
AARR00000000

Software Mentioned

EvoPrinter
BLASTp
EvoDifference
EvoUnique
BLAT
EvoPrinterHD
EvoPrint
BLASTn
EvoDifferences
tBLASTn

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.