Horizontal transfer of antibiotic resistance genes in the human gut microbiome.

Current Opinion in Microbiology
Ross S McInnesWillem van Schaik

Abstract

Infections caused by antibiotic-resistant bacteria are a major threat to public health. The pathogens causing these infections can acquire antibiotic resistance genes in a process termed horizontal gene transfer (HGT). HGT is a common event in the human gut microbiome, that is, the microbial ecosystem of the human intestinal tract. HGT in the gut microbiome can occur via different mechanisms of which transduction and conjugation have been best characterised. Novel bioinformatic tools and experimental approaches have been developed to determine the association of antibiotic resistance genes with their microbial hosts and to quantify the extent of HGT in the gut microbiome. Insights from studies into HGT in the gut microbiome may lead to the development of novel interventions to minimise the spread of antibiotic resistance genes among commensals and opportunistic pathogens.

Citations

Jul 17, 2020·Gut Pathogens·Chen LiShuai Cheng Li
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Emma Guerin, Colin Hill
Nov 18, 2020·Critical Reviews in Food Science and Nutrition·Hui DuanWei Chen
Jan 6, 2021·Communications Biology·Stefan EbmeyerD G Joakim Larsson
Feb 15, 2021·Cellular and Molecular Life Sciences : CMLS·Kevin S BlakeGautam Dantas
Jun 3, 2021·Antibiotics·Maira GoytiaKacey A King
Jul 24, 2021·Journal of Environmental Management·Sakina BombaywalaNishant A Dafale
Jul 18, 2021·Journal of Hazardous Materials·Guanqun FengYinguang Chen
Jan 26, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Irene N KasumbaSharon M Tennant
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bartosz HornikAgnieszka Piotrowska-Cyplik

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