Horizontal transmission of Candida albicans and evidence of a vaccine response in mice colonized with the fungus

PloS One
Jim E CutlerHong Xin

Abstract

Disseminated candidiasis is the third leading nosocomial blood stream infection in the United States and is often fatal. We previously showed that disseminated candidiasis was preventable in normal mice by immunization with either a glycopeptide or a peptide synthetic vaccine, both of which were Candida albicans cell wall derived. A weakness of these studies is that, unlike humans, mice do not have a C. albicans GI flora and they lack Candida serum antibodies. We examined the influence of C. albicans GI tract colonization and serum antibodies on mouse vaccination responses to the peptide, Fba, derived from fructose bisphosphate aldolase which has cytosolic and cell wall distributions in the fungus. We evaluated the effect of live C. albicans in drinking water and antimicrobial agents on establishment of Candida colonization of the mouse GI tract. Body mass, C. albicans in feces, and fungal-specific serum antibodies were monitored longitudinally. Unexpectedly, C. albicans colonization occurred in mice that received only antibiotics in their drinking water, provided that the mice were housed in the same room as intentionally colonized mice. The fungal strain in unintentionally colonized mice appeared identical to the strain used ...Continue Reading

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Aug 25, 2015·Frontiers in Microbiology·Daniel Prieto, Jesús Pla
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Methods Mentioned

BETA
ELISA

Related Concepts

Antibiotics
Antibodies, Fungal
Antibody Formation
Candida albicans
Candidiasis
Fungal Vaccines
Mice, Inbred C57BL
Pilot Projects
Vaccination
Streak Plate Count

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