Hormesis and Cellular Quality Control: A Possible Explanation for the Molecular Mechanisms that Underlie the Benefits of Mild Stress

Dose-response : a Publication of International Hormesis Society
F A C WiegantA M A Schreij

Abstract

In contrast to the detrimental action of severe stress conditions, the beneficial effects of mild stress, known as hormesis, is increasingly discussed and studied. A variety of applications for hormesis in risk assessment processes, anti-ageing strategies and clinical therapies have been proposed. The molecular mechanisms underlying the phenomenon of hormesis, however, are not yet fully understood. A possible mechanism that has been proposed for hormesis, the homoeostasis overshoot hypothesis, assumes that an overshoot of repair- and self-recovery mechanisms in response to mild damage can be held responsible for the beneficial effects of hormesis. The present paper proposes 'cellular quality control' as a further explanation of the molecular mechanisms underlying the benefits observed after exposure to mild stress. The most important quality control mechanisms are outlined and their known and hypothesised actions in hormesis are discussed. As an example, different aspects of protein quality control will be described in more detail, which includes the reaction of the cell upon stress-induced protein damage and -aggregation. The regulation of Heat Shock Proteins and components from the ubiquitin proteasome system as part of cellu...Continue Reading

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Sep 16, 2016·Cell Cycle·Marta Markiewicz-Potoczny, David Lydall
Apr 14, 2016·Dose-response : a Publication of International Hormesis Society·Sonia LippkeRalf Schwarzer
May 20, 2016·Neuromolecular Medicine·Joonki KimThiruma V Arumugam
Apr 11, 2020·Dose-response : a Publication of International Hormesis Society·Polina Yu VolkovaM A Lychenkova
Jun 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P K LakshmiRajesh Singh Pawar

Methods Mentioned

BETA
Protein folding
nuclear translocation

Related Concepts

General Adaptation Syndrome
Heat shock proteins
Ubiquitin
Risk Assessment
Cell Injury
Iodine MILD
Cellularization
Regulation of Biological Process
Repair - Remedial Action
Recovery - Healing Process

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