Hormetic effects by exercise on hippocampal neurogenesis with glucocorticoid signaling

Brain Plasticity
M OkamotoH Soya

Abstract

Exercise enhances adult hippocampal neurogenesis (AHN), although the exact nature of how this happens remains controversial. The beneficial effects of exercise vary depending upon the exercise condition, especially intensity. Most animal studies, however, have used wheel running, which only evaluates running distance (exercise volume) and does not consider intensity. In our rat model, we have found that exercise-induced neurogenesis varies depending on the intensity of the exercise and have found that exercise-enhanced neurogenesis is more pronounced with mild exercise than with moderate and/or intense exercise. This may be due, at least in part, to increased glucocorticoid (CORT) secretion. To test this hypothesis, we used our special exercise model in mice, with and without a stress response, based on the lactate threshold (LT) in which moderate exercise above the LT increases lactate and adrenocorticotropic hormone (ACTH) release, while mild exercise does not. Adult male C57BL/6J mice were subjected to two weeks of exercise training and AHN was measured with a 5-Bromo-2-deoxyuridine (BrdU) pre-injection and immunohistochemistry. The role of glucocorticoid signaling was examined using intrapertioneal injections of antagonists...Continue Reading

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Citations

Oct 9, 2015·Brain Plasticity·Henriette van Praag, Brian Christie
Jun 11, 2019·Frontiers in Neuroscience·Yaeli Lev-VachnishEitan Okun
Sep 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kazuya SuwabeHideaki Soya
Mar 26, 2016·Frontiers in Neuroscience·Simona GradariJosé L Trejo
Feb 5, 2016·The Journal of Physiology·Miriam S NokiaHeikki Kainulainen
Dec 11, 2020·Journal of Neurochemistry·Oleg V Podgorny, Natalia V Gulyaeva
May 8, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Luis E B BettioJoana Gil-Mohapel
Apr 2, 2021·Stress : the International Journal on the Biology of Stress·Daniele J FerianiBruno Rodrigues
Jul 25, 2021·International Journal of Molecular Sciences·Julia LeschikAntonietta Gentile

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